# TGF-β signaling in diseases

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/tgf-signaling-in-diseases/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the diverse aspects of the Transforming Growth Factor Beta (TGF-ß) signaling pathway, including its role in Smad-dependent and Smad-independent pathways, tumor suppression, cancer progression, bone morphogenetic protein (BMP) signaling, immune response modulation, cell differentiation, metastasis, regulation of epithelial-mesenchymal transition (EMT), and angiogenesis. It also discusses the development and use of TGF-ß inhibitors for potential therapeutic interventions. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11501 |
| Works | 155 |

## Topic papers all

Showing 15 of 155.

- [The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling](https://scholariq.org/papers/the-mad-related-protein-smad7-associates-with-the-tgf-receptor-and-functions-as/)
- [Bone morphogenetic proteins inhibit the tumorigenic potential of human brain tumour-initiating cells](https://scholariq.org/papers/bone-morphogenetic-proteins-inhibit-the-tumorigenic-potential-of-human-brain/)
- [Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis](https://scholariq.org/papers/inhibition-of-tgf-signaling-in-mesenchymal-stem-cells-of-subchondral-bone/)
- [Treatment of Acromegaly with the Growth Hormone–Receptor Antagonist Pegvisomant](https://scholariq.org/papers/treatment-of-acromegaly-with-the-growth-hormone-receptor-antagonist-pegvisomant/)
- [Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions.](https://scholariq.org/papers/hepatic-expression-of-mature-transforming-growth-factor-beta-1-in-transgenic/)
- [Targeting the TGFβ pathway for cancer therapy](https://scholariq.org/papers/targeting-the-tgf-pathway-for-cancer-therapy/)
- [TGF-β and fibrosis](https://scholariq.org/papers/tgf-and-fibrosis/)
- [TGF-β and fibrosis in different organs — molecular pathway imprints](https://scholariq.org/papers/tgf-and-fibrosis-in-different-organs-molecular-pathway-imprints/)
- [High Doses of Bone Morphogenetic Protein 2 Induce Structurally Abnormal Bone and Inflammation <i>In Vivo</i>](https://scholariq.org/papers/high-doses-of-bone-morphogenetic-protein-2-induce-structurally-abnormal-bone-and/)
- [A microRNA signature for a BMP2-induced osteoblast lineage commitment program](https://scholariq.org/papers/a-microrna-signature-for-a-bmp2-induced-osteoblast-lineage-commitment-program/)
- [Runx2 control of organization, assembly and activity of the regulatory machinery for skeletal gene expression](https://scholariq.org/papers/runx2-control-of-organization-assembly-and-activity-of-the-regulatory-machinery/)
- [SMAD4-dependent barrier constrains prostate cancer growth and metastatic progression](https://scholariq.org/papers/smad4-dependent-barrier-constrains-prostate-cancer-growth-and-metastatic/)
- [Cartilage-inducing factor-A. Apparent identity to transforming growth factor-beta.](https://scholariq.org/papers/cartilage-inducing-factor-a-apparent-identity-to-transforming-growth-factor-beta/)
- [Vascular development: cellular and molecular regulation](https://scholariq.org/papers/vascular-development-cellular-and-molecular-regulation/)
- [The good and the bad collagens of fibrosis – Their role in signaling and organ function](https://scholariq.org/papers/the-good-and-the-bad-collagens-of-fibrosis-their-role-in-signaling-and-organ/)

## Topic primary papers

Showing 15 of 55.

- [The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling](https://scholariq.org/papers/the-mad-related-protein-smad7-associates-with-the-tgf-receptor-and-functions-as/)
- [Targeting the TGFβ pathway for cancer therapy](https://scholariq.org/papers/targeting-the-tgf-pathway-for-cancer-therapy/)
- [TGF-β and fibrosis in different organs — molecular pathway imprints](https://scholariq.org/papers/tgf-and-fibrosis-in-different-organs-molecular-pathway-imprints/)
- [TβRI Phosphorylation of Smad2 on Ser465 and Ser467 Is Required for Smad2-Smad4 Complex Formation and Signaling](https://scholariq.org/papers/t-ri-phosphorylation-of-smad2-on-ser465-and-ser467-is-required-for-smad2-smad4/)
- [Transcriptional control of osteoblast growth and differentiation](https://scholariq.org/papers/transcriptional-control-of-osteoblast-growth-and-differentiation/)
- [Mongersen, an Oral <i>SMAD7</i> Antisense Oligonucleotide, and Crohn’s Disease](https://scholariq.org/papers/mongersen-an-oral-i-smad7-i-antisense-oligonucleotide-and-crohn-s-disease/)
- [Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity.](https://scholariq.org/papers/activin-receptor-like-kinases-a-novel-subclass-of-cell-surface-receptors-with/)
- [Endothelial Cells Modulate the Proliferation of Mural Cell Precursors via Platelet-Derived Growth Factor-BB and Heterotypic Cell Contact](https://scholariq.org/papers/endothelial-cells-modulate-the-proliferation-of-mural-cell-precursors-via/)
- [Cartilage-inducing factor-B is a unique protein structurally and functionally related to transforming growth factor-beta.](https://scholariq.org/papers/cartilage-inducing-factor-b-is-a-unique-protein-structurally-and-functionally/)
- [TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma](https://scholariq.org/papers/tgf-blockade-improves-the-distribution-and-efficacy-of-therapeutics-in-breast/)
- [Transforming growth factor-β: A therapeutic target for cancer](https://scholariq.org/papers/transforming-growth-factor-a-therapeutic-target-for-cancer/)
- [Diverse Role of TGF-β in Kidney Disease](https://scholariq.org/papers/diverse-role-of-tgf-in-kidney-disease/)
- [Localisation of PGK1 determines metabolic phenotype to balance metastasis and proliferation in patients with SMAD4-negative pancreatic cancer](https://scholariq.org/papers/localisation-of-pgk1-determines-metabolic-phenotype-to-balance-metastasis-and/)
- [The Six1 homeoprotein induces human mammary carcinoma cells to undergo epithelial-mesenchymal transition and metastasis in mice through increasing TGF-β signaling](https://scholariq.org/papers/the-six1-homeoprotein-induces-human-mammary-carcinoma-cells-to-undergo/)
- [Distinct mechanisms of TGF- 1-mediated epithelial-to-mesenchymal transition and metastasis during skin carcinogenesis](https://scholariq.org/papers/distinct-mechanisms-of-tgf-1-mediated-epithelial-to-mesenchymal-transition-and/)

---
Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.