# Tryptophan and brain disorders

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/tryptophan-and-brain-disorders/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers explores the intricate relationship between the immune system and the brain, focusing on neuroinflammation, cytokine signaling, and the impact of immune activation on psychiatric disorders such as depression and schizophrenia. The role of tryptophan metabolism, oxidative stress, and maternal immune activation in influencing brain function and behavior is also a key area of investigation. |
| Domain | Life Sciences |
| Field | Neuroscience |
| OpenAlex ID | t11337 |
| Works | 475 |

## Topic papers all

Showing 15 of 475.

- [Biological insights from 108 schizophrenia-associated genetic loci](https://scholariq.org/papers/biological-insights-from-108-schizophrenia-associated-genetic-loci/)
- [Lecanemab in Early Alzheimer’s Disease](https://scholariq.org/papers/lecanemab-in-early-alzheimer-s-disease/)
- [A Randomized Trial of an N-methyl-D-aspartate Antagonist in Treatment-Resistant Major Depression](https://scholariq.org/papers/a-randomized-trial-of-an-n-methyl-d-aspartate-antagonist-in-treatment-resistant/)
- [Subgenual prefrontal cortex abnormalities in mood disorders](https://scholariq.org/papers/subgenual-prefrontal-cortex-abnormalities-in-mood-disorders/)
- [Schizophrenia](https://scholariq.org/papers/schizophrenia/)
- [Global Epidemiology and Burden of Schizophrenia: Findings From the Global Burden of Disease Study 2016](https://scholariq.org/papers/global-epidemiology-and-burden-of-schizophrenia-findings-from-the-global-burden/)
- [Bipolar disorder](https://scholariq.org/papers/bipolar-disorder/)
- [Salt-responsive gut commensal modulates TH17 axis and disease](https://scholariq.org/papers/salt-responsive-gut-commensal-modulates-th17-axis-and-disease/)
- [Role of pro-inflammatory cytokines released from microglia in Alzheimer's disease.](https://scholariq.org/papers/role-of-pro-inflammatory-cytokines-released-from-microglia-in-alzheimer-s/)
- [Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism](https://scholariq.org/papers/impact-of-the-gut-microbiota-on-intestinal-immunity-mediated-by-tryptophan/)
- [Depression and risk of developing dementia](https://scholariq.org/papers/depression-and-risk-of-developing-dementia/)
- [Roles of IFN-γ in tumor progression and regression: a review](https://scholariq.org/papers/roles-of-ifn-in-tumor-progression-and-regression-a-review/)
- [Neural correlates of the psychedelic state as determined by fMRI studies with psilocybin](https://scholariq.org/papers/neural-correlates-of-the-psychedelic-state-as-determined-by-fmri-studies-with/)
- [The cellular neurobiology of depression](https://scholariq.org/papers/the-cellular-neurobiology-of-depression/)
- [Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression](https://scholariq.org/papers/sodium-oligomannate-therapeutically-remodels-gut-microbiota-and-suppresses-gut/)

## Topic primary papers

Showing 15 of 128.

- [Impact of the Gut Microbiota on Intestinal Immunity Mediated by Tryptophan Metabolism](https://scholariq.org/papers/impact-of-the-gut-microbiota-on-intestinal-immunity-mediated-by-tryptophan/)
- [The cellular neurobiology of depression](https://scholariq.org/papers/the-cellular-neurobiology-of-depression/)
- [Sodium oligomannate therapeutically remodels gut microbiota and suppresses gut bacterial amino acids-shaped neuroinflammation to inhibit Alzheimer’s disease progression](https://scholariq.org/papers/sodium-oligomannate-therapeutically-remodels-gut-microbiota-and-suppresses-gut/)
- [Association of Serum Interleukin 6 and C-Reactive Protein in Childhood With Depression and Psychosis in Young Adult Life](https://scholariq.org/papers/association-of-serum-interleukin-6-and-c-reactive-protein-in-childhood-with/)
- [Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes](https://scholariq.org/papers/expression-of-indoleamine-2-3-dioxygenase-by-plasmacytoid-dendritic-cells-in/)
- [Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels](https://scholariq.org/papers/prevalence-of-low-grade-inflammation-in-depression-a-systematic-review-and-meta/)
- [Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation](https://scholariq.org/papers/indoleamine-2-3-dioxygenase-production-by-human-dendritic-cells-results-in-the/)
- [Antidepressant activity of anti-cytokine treatment: a systematic review and meta-analysis of clinical trials of chronic inflammatory conditions](https://scholariq.org/papers/antidepressant-activity-of-anti-cytokine-treatment-a-systematic-review-and-meta/)
- [COVID-19 infection alters kynurenine and fatty acid metabolism, correlating with IL-6 levels and renal status](https://scholariq.org/papers/covid-19-infection-alters-kynurenine-and-fatty-acid-metabolism-correlating-with/)
- [R-ketamine: a rapid-onset and sustained antidepressant without psychotomimetic side effects](https://scholariq.org/papers/r-ketamine-a-rapid-onset-and-sustained-antidepressant-without-psychotomimetic/)
- [Myeloid-Derived Suppressor Cells Suppress Antitumor Immune Responses through IDO Expression and Correlate with Lymph Node Metastasis in Patients with Breast Cancer](https://scholariq.org/papers/myeloid-derived-suppressor-cells-suppress-antitumor-immune-responses-through-ido/)
- [Inverse association of anti‐inflammatory treatments and Alzheimer's disease](https://scholariq.org/papers/inverse-association-of-anti-inflammatory-treatments-and-alzheimer-s-disease/)
- [Brain-derived Neurotrophic Factor (BDNF)-TrkB Signaling in Inflammation-related Depression and Potential Therapeutic Targets](https://scholariq.org/papers/brain-derived-neurotrophic-factor-bdnf-trkb-signaling-in-inflammation-related/)
- [Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression](https://scholariq.org/papers/altered-expression-of-genes-involved-in-inflammation-and-apoptosis-in-frontal/)
- [Chronic stress and immunity in family caregivers of Alzheimerʼs disease victims.](https://scholariq.org/papers/chronic-stress-and-immunity-in-family-caregivers-of-alzheimer-s-disease-victims/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.