# Ubiquitin and proteasome pathways
**Type:** Topics
**Canonical URL:** https://scholariq.org/topics/ubiquitin-and-proteasome-pathways/
## Facts
| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the Ubiquitin-Proteasome Proteolytic Pathway, exploring mechanisms of protein degradation, regulation of E3 Ubiquitin Ligases, roles of Deubiquitinating Enzymes, and the impact of SUMOylation. It also delves into the development of proteasome inhibitors for cancer therapy and the involvement of this pathway in NF-?B activation. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t11041 |
| Works | 266 |
## Topic papers all
Showing 15 of 266.
- [Lenalidomide Causes Selective Degradation of IKZF1 and IKZF3 in Multiple Myeloma Cells](https://scholariq.org/papers/lenalidomide-causes-selective-degradation-of-ikzf1-and-ikzf3-in-multiple-myeloma/)
- [Rett syndrome: Revised diagnostic criteria and nomenclature](https://scholariq.org/papers/rett-syndrome-revised-diagnostic-criteria-and-nomenclature/)
- [Catalytic in vivo protein knockdown by small-molecule PROTACs](https://scholariq.org/papers/catalytic-in-vivo-protein-knockdown-by-small-molecule-protacs/)
- [Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila](https://scholariq.org/papers/histone-deacetylase-inhibitors-arrest-polyglutamine-dependent-neurodegeneration/)
- [Teclistamab in Relapsed or Refractory Multiple Myeloma](https://scholariq.org/papers/teclistamab-in-relapsed-or-refractory-multiple-myeloma/)
- [Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4](https://scholariq.org/papers/hijacking-the-e3-ubiquitin-ligase-cereblon-to-efficiently-target-brd4/)
- [Integrated Proteogenomic Characterization of Human High-Grade Serous Ovarian Cancer](https://scholariq.org/papers/integrated-proteogenomic-characterization-of-human-high-grade-serous-ovarian/)
- [Rb1 and Trp53 cooperate to suppress prostate cancer lineage plasticity, metastasis, and antiandrogen resistance](https://scholariq.org/papers/i-rb1-i-and-i-trp53-i-cooperate-to-suppress-prostate-cancer-lineage-plasticity/)
- [Symbol Nomenclature for Graphical Representations of Glycans](https://scholariq.org/papers/symbol-nomenclature-for-graphical-representations-of-glycans/)
- [Hypoxia Inducible Factor-α Binding and Ubiquitylation by the von Hippel-Lindau Tumor Suppressor Protein](https://scholariq.org/papers/hypoxia-inducible-factor-binding-and-ubiquitylation-by-the-von-hippel-lindau/)
- [Cellular mechanisms of tumour suppression by the retinoblastoma gene](https://scholariq.org/papers/cellular-mechanisms-of-tumour-suppression-by-the-retinoblastoma-gene/)
- [The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro](https://scholariq.org/papers/the-scfbeta-trcp-ubiquitin-ligase-complex-associates-specifically-with/)
- [A family of human cdc2‐related protein kinases.](https://scholariq.org/papers/a-family-of-human-cdc2-related-protein-kinases/)
- [Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead](https://scholariq.org/papers/lessons-in-protac-design-from-selective-degradation-with-a-promiscuous-warhead/)
- [PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer](https://scholariq.org/papers/protac-induced-bet-protein-degradation-as-a-therapy-for-castration-resistant/)
## Topic primary papers
Showing 15 of 67.
- [The SCFbeta -TRCP-ubiquitin ligase complex associates specifically with phosphorylated destruction motifs in Ikappa Balpha and beta -catenin and stimulates Ikappa Balpha ubiquitination in vitro](https://scholariq.org/papers/the-scfbeta-trcp-ubiquitin-ligase-complex-associates-specifically-with/)
- [How the ubiquitin–proteasome system controls transcription](https://scholariq.org/papers/how-the-ubiquitin-proteasome-system-controls-transcription/)
- [The role of ubiquitination in tumorigenesis and targeted drug discovery](https://scholariq.org/papers/the-role-of-ubiquitination-in-tumorigenesis-and-targeted-drug-discovery/)
- [SCFFBW7 regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction](https://scholariq.org/papers/scffbw7-regulates-cellular-apoptosis-by-targeting-mcl1-for-ubiquitylation-and/)
- [Evaluation of the Proteasome Inhibitor MLN9708 in Preclinical Models of Human Cancer](https://scholariq.org/papers/evaluation-of-the-proteasome-inhibitor-mln9708-in-preclinical-models-of-human/)
- [Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.](https://scholariq.org/papers/turnover-of-cyclin-e-by-the-ubiquitin-proteasome-pathway-is-regulated-by-cdk2/)
- [A small-molecule inhibitor of the ubiquitin activating enzyme for cancer treatment](https://scholariq.org/papers/a-small-molecule-inhibitor-of-the-ubiquitin-activating-enzyme-for-cancer/)
- [Proteins containing the UBA domain are able to bind to multi-ubiquitin chains](https://scholariq.org/papers/proteins-containing-the-uba-domain-are-able-to-bind-to-multi-ubiquitin-chains/)
- [A novel protein complex involved in signal transduction possessing similarities to 26S proteasome subunits](https://scholariq.org/papers/a-novel-protein-complex-involved-in-signal-transduction-possessing-similarities/)
- [Integrated Proteogenomic Characterization across Major Histological Types of Pediatric Brain Cancer](https://scholariq.org/papers/integrated-proteogenomic-characterization-across-major-histological-types-of/)
- [Phosphorylation-Dependent Ubiquitination of Cyclin D1 by the SCFFBX4-αB Crystallin Complex](https://scholariq.org/papers/phosphorylation-dependent-ubiquitination-of-cyclin-d1-by-the-scffbx4-b/)
- [Rpn1 provides adjacent receptor sites for substrate binding and deubiquitination by the proteasome](https://scholariq.org/papers/rpn1-provides-adjacent-receptor-sites-for-substrate-binding-and-deubiquitination/)
- [Proteasome assembly defect due to a proteasome subunit beta type 8 (PSMB8) mutation causes the autoinflammatory disorder, Nakajo-Nishimura syndrome](https://scholariq.org/papers/proteasome-assembly-defect-due-to-a-proteasome-subunit-beta-type-8-psmb8/)
- [RSUME, a Small RWD-Containing Protein, Enhances SUMO Conjugation and Stabilizes HIF-1α during Hypoxia](https://scholariq.org/papers/rsume-a-small-rwd-containing-protein-enhances-sumo-conjugation-and-stabilizes/)
- [A six-nucleotide insertion-deletion polymorphism in the CASP8 promoter is associated with susceptibility to multiple cancers](https://scholariq.org/papers/a-six-nucleotide-insertion-deletion-polymorphism-in-the-casp8-promoter-is/)
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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.