# Virus-based gene therapy research **Type:** Topics **Canonical URL:** https://scholariq.org/topics/virus-based-gene-therapy-research/ ## Facts | Field | Value | | --- | --- | | Description | This cluster of papers covers a wide range of topics related to gene therapy, including the use of viral vectors such as AAV and adenovirus, advancements in oncolytic virus therapy, hematopoietic stem cell gene therapy, immunodeficiency treatments, lentiviral vector applications, transgene expression, and genomic integration. The research reflects the ongoing progress and challenges in the field of gene therapy. | | Domain | Life Sciences | | Field | Biochemistry, Genetics and Molecular Biology | | OpenAlex ID | t10613 | | Works | 255 | ## Topic papers all Showing 15 of 255. - [Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia](https://scholariq.org/papers/tisagenlecleucel-in-children-and-young-adults-with-b-cell-lymphoblastic-leukemia/) - [LMO2 -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1](https://scholariq.org/papers/i-lmo2-i-associated-clonal-t-cell-proliferation-in-two-patients-after-gene/) - [Cancer Regression and Autoimmunity in Patients After Clonal Repopulation with Antitumor Lymphocytes](https://scholariq.org/papers/cancer-regression-and-autoimmunity-in-patients-after-clonal-repopulation-with/) - [Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes](https://scholariq.org/papers/cancer-regression-in-patients-after-transfer-of-genetically-engineered/) - [Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia](https://scholariq.org/papers/efficacy-and-toxicity-management-of-19-28z-car-t-cell-therapy-in-b-cell-acute/) - [Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response](https://scholariq.org/papers/successful-transduction-of-liver-in-hemophilia-by-aav-factor-ix-and-limitations/) - [Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial](https://scholariq.org/papers/efficacy-assessment-of-a-cell-mediated-immunity-hiv-1-vaccine-the-step-study-a/) - [Adoptive Cell Transfer Therapy Following Non-Myeloablative but Lymphodepleting Chemotherapy for the Treatment of Patients With Refractory Metastatic Melanoma](https://scholariq.org/papers/adoptive-cell-transfer-therapy-following-non-myeloablative-but-lymphodepleting/) - [In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors](https://scholariq.org/papers/in-vivo-gene-transfer-with-retroviral-vector-producer-cells-for-treatment-of/) - [Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial](https://scholariq.org/papers/safety-tolerability-and-immunogenicity-of-a-recombinant-adenovirus-type-5/) - [Gene therapy comes of age](https://scholariq.org/papers/gene-therapy-comes-of-age/) - [Generation of influenza A viruses entirely from cloned cDNAs](https://scholariq.org/papers/generation-of-influenza-a-viruses-entirely-from-cloned-cdnas/) - [Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial](https://scholariq.org/papers/immunogenicity-and-safety-of-a-recombinant-adenovirus-type-5-vectored-covid-19/) - [Emergence of Fatal PRRSV Variants: Unparalleled Outbreaks of Atypical PRRS in China and Molecular Dissection of the Unique Hallmark](https://scholariq.org/papers/emergence-of-fatal-prrsv-variants-unparalleled-outbreaks-of-atypical-prrs-in/) - [Safety and tolerability of gene therapy with an adeno-associated virus (AAV) borne GAD gene for Parkinson's disease: an open label, phase I trial](https://scholariq.org/papers/safety-and-tolerability-of-gene-therapy-with-an-adeno-associated-virus-aav-borne/) ## Topic primary papers Showing 15 of 91. - [Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response](https://scholariq.org/papers/successful-transduction-of-liver-in-hemophilia-by-aav-factor-ix-and-limitations/) - [In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors](https://scholariq.org/papers/in-vivo-gene-transfer-with-retroviral-vector-producer-cells-for-treatment-of/) - [Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial](https://scholariq.org/papers/safety-tolerability-and-immunogenicity-of-a-recombinant-adenovirus-type-5/) - [Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial](https://scholariq.org/papers/immunogenicity-and-safety-of-a-recombinant-adenovirus-type-5-vectored-covid-19/) - [Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues](https://scholariq.org/papers/clades-of-adeno-associated-viruses-are-widely-disseminated-in-human-tissues/) - [Lentiviral Hematopoietic Stem Cell Gene Therapy in Patients with Wiskott-Aldrich Syndrome](https://scholariq.org/papers/lentiviral-hematopoietic-stem-cell-gene-therapy-in-patients-with-wiskott-aldrich/) - [Role of a p53 polymorphism in the development of human papilloma-virus-associated cancer](https://scholariq.org/papers/role-of-a-p53-polymorphism-in-the-development-of-human-papilloma-virus/) - [Recurrent Glioblastoma Treated with Recombinant Poliovirus](https://scholariq.org/papers/recurrent-glioblastoma-treated-with-recombinant-poliovirus/) - [Gene Therapy for Wiskott-Aldrich Syndrome—Long-Term Efficacy and Genotoxicity](https://scholariq.org/papers/gene-therapy-for-wiskott-aldrich-syndrome-long-term-efficacy-and-genotoxicity/) - [Hyperthermic Oncology 1984](https://scholariq.org/papers/hyperthermic-oncology-1984/) - [Calcium upregulation by percutaneous administration of gene therapy in patients with cardiac disease (CUPID 2): a randomised, multinational, double-blind, placebo-controlled, phase 2b trial](https://scholariq.org/papers/calcium-upregulation-by-percutaneous-administration-of-gene-therapy-in-patients/) - [Adenovirus-Mediated p53 Gene Transfer in Advanced Non-Small-Cell Lung Cancer](https://scholariq.org/papers/adenovirus-mediated-p53-gene-transfer-in-advanced-non-small-cell-lung-cancer/) - [Adenoviral Gene Therapy Leads to Rapid Induction of Multiple Chemokines and Acute Neutrophil-Dependent Hepatic Injury in Vivo](https://scholariq.org/papers/adenoviral-gene-therapy-leads-to-rapid-induction-of-multiple-chemokines-and/) - [Long-term safety and tolerability of ProSavin, a lentiviral vector-based gene therapy for Parkinson's disease: a dose escalation, open-label, phase 1/2 trial](https://scholariq.org/papers/long-term-safety-and-tolerability-of-prosavin-a-lentiviral-vector-based-gene/) - [A Modified γ-Retrovirus Vector for X-Linked Severe Combined Immunodeficiency](https://scholariq.org/papers/a-modified-retrovirus-vector-for-x-linked-severe-combined-immunodeficiency/) --- Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.