# Wnt/β-catenin signaling in development and cancer

**Type:** Topics  
**Canonical URL:** https://scholariq.org/topics/wnt-catenin-signaling-in-development-and-cancer/

## Facts

| Field | Value |
| --- | --- |
| Description | This cluster of papers focuses on the Wnt signaling pathway and its role in development, stem cells, cancer, and disease. It covers components, mechanisms, diseases, therapeutic modalities, and the impact of Wnt signaling on osteoblast and chondrocyte differentiation. |
| Domain | Life Sciences |
| Field | Biochemistry, Genetics and Molecular Biology |
| OpenAlex ID | t10929 |
| Works | 178 |

## Topic papers all

Showing 15 of 178.

- [Wnt activity defines colon cancer stem cells and is regulated by the microenvironment](https://scholariq.org/papers/wnt-activity-defines-colon-cancer-stem-cells-and-is-regulated-by-the/)
- [APP locus duplication causes autosomal dominant early-onset Alzheimer disease with cerebral amyloid angiopathy](https://scholariq.org/papers/app-locus-duplication-causes-autosomal-dominant-early-onset-alzheimer-disease/)
- [Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression](https://scholariq.org/papers/canonical-wnt-signaling-promotes-osteogenesis-by-directly-stimulating-runx2-gene/)
- [Identification and characterization of a fibroblast marker: FSP1.](https://scholariq.org/papers/identification-and-characterization-of-a-fibroblast-marker-fsp1/)
- [β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma](https://scholariq.org/papers/catenin-activation-promotes-immune-escape-and-resistance-to-anti-pd-1-therapy-in/)
- [Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs](https://scholariq.org/papers/breast-cancer-cells-produce-tenascin-c-as-a-metastatic-niche-component-to/)
- [Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver](https://scholariq.org/papers/hippo-signaling-is-a-potent-in-vivo-growth-and-tumor-suppressor-pathway-in-the/)
- [The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer](https://scholariq.org/papers/the-8q24-cancer-risk-variant-rs6983267-shows-long-range-interaction-with-myc-in/)
- [The Laminin α Chains: Expression, Developmental Transitions, and Chromosomal Locations of α1-5, Identification of Heterotrimeric Laminins 8–11, and Cloning of a Novel α3 Isoform](https://scholariq.org/papers/the-laminin-chains-expression-developmental-transitions-and-chromosomal/)
- [Translation of the circular RNA circβ-catenin promotes liver cancer cell growth through activation of the Wnt pathway](https://scholariq.org/papers/translation-of-the-circular-rna-circ-catenin-promotes-liver-cancer-cell-growth/)
- [p160<sup>ROCK</sup>, a Rho‐associated coiled‐coil forming protein kinase, works downstream of Rho and induces focal adhesions](https://scholariq.org/papers/p160-sup-rock-sup-a-rho-associated-coiled-coil-forming-protein-kinase-works/)
- [Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity](https://scholariq.org/papers/sfrp5-is-an-anti-inflammatory-adipokine-that-modulates-metabolic-dysfunction-in/)
- [Scar-Associated Macrophages Are a Major Source of Hepatic Matrix Metalloproteinase-13 and Facilitate the Resolution of Murine Hepatic Fibrosis](https://scholariq.org/papers/scar-associated-macrophages-are-a-major-source-of-hepatic-matrix/)
- [The Role of Maternal VegT in Establishing the Primary Germ Layers in Xenopus Embryos](https://scholariq.org/papers/the-role-of-maternal-vegt-in-establishing-the-primary-germ-layers-in-xenopus/)
- [Fat1 deletion promotes hybrid EMT state, tumour stemness and metastasis](https://scholariq.org/papers/fat1-deletion-promotes-hybrid-emt-state-tumour-stemness-and-metastasis/)

## Topic primary papers

Showing 15 of 65.

- [Canonical WNT Signaling Promotes Osteogenesis by Directly Stimulating Runx2 Gene Expression](https://scholariq.org/papers/canonical-wnt-signaling-promotes-osteogenesis-by-directly-stimulating-runx2-gene/)
- [β-Catenin Activation Promotes Immune Escape and Resistance to Anti–PD-1 Therapy in Hepatocellular Carcinoma](https://scholariq.org/papers/catenin-activation-promotes-immune-escape-and-resistance-to-anti-pd-1-therapy-in/)
- [Sfrp5 Is an Anti-Inflammatory Adipokine That Modulates Metabolic Dysfunction in Obesity](https://scholariq.org/papers/sfrp5-is-an-anti-inflammatory-adipokine-that-modulates-metabolic-dysfunction-in/)
- [The Wnt Co-receptor LRP5 Is Essential for Skeletal Mechanotransduction but Not for the Anabolic Bone Response to Parathyroid Hormone Treatment](https://scholariq.org/papers/the-wnt-co-receptor-lrp5-is-essential-for-skeletal-mechanotransduction-but-not/)
- [Novel markers for differentiation of lobular and ductal invasive breast carcinomas by laser microdissection and microarray analysis](https://scholariq.org/papers/novel-markers-for-differentiation-of-lobular-and-ductal-invasive-breast/)
- [Dynamic and Static Interactions between p120 Catenin and E-Cadherin Regulate the Stability of Cell-Cell Adhesion](https://scholariq.org/papers/dynamic-and-static-interactions-between-p120-catenin-and-e-cadherin-regulate-the/)
- [Desmoglein 1 deficiency results in severe dermatitis, multiple allergies and metabolic wasting](https://scholariq.org/papers/desmoglein-1-deficiency-results-in-severe-dermatitis-multiple-allergies-and/)
- [Recessive Robinow syndrome, allelic to dominant brachydactyly type B, is caused by mutation of ROR2](https://scholariq.org/papers/recessive-robinow-syndrome-allelic-to-dominant-brachydactyly-type-b-is-caused-by/)
- [The Wnt Inhibitor Sclerostin Is Up-regulated by Mechanical Unloading in Osteocytes in Vitro](https://scholariq.org/papers/the-wnt-inhibitor-sclerostin-is-up-regulated-by-mechanical-unloading-in/)
- [Frequent Nuclear/Cytoplasmic Localization of β-Catenin without Exon 3 Mutations in Malignant Melanoma](https://scholariq.org/papers/frequent-nuclear-cytoplasmic-localization-of-catenin-without-exon-3-mutations-in/)
- [PLAGL2 Regulates Wnt Signaling to Impede Differentiation in Neural Stem Cells and Gliomas](https://scholariq.org/papers/plagl2-regulates-wnt-signaling-to-impede-differentiation-in-neural-stem-cells/)
- [Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances](https://scholariq.org/papers/wnt-signaling-pathways-in-biology-and-disease-mechanisms-and-therapeutic/)
- [Role of DAB2IP in modulating epithelial-to-mesenchymal transition and prostate cancer metastasis](https://scholariq.org/papers/role-of-dab2ip-in-modulating-epithelial-to-mesenchymal-transition-and-prostate/)
- [Quercetin Inhibit Human SW480 Colon Cancer Growth in Association with Inhibition of Cyclin D<sub>1</sub>and Survivin Expression through Wnt/β-Catenin Signaling Pathway](https://scholariq.org/papers/quercetin-inhibit-human-sw480-colon-cancer-growth-in-association-with-inhibition/)
- [Stabilization of β-catenin by a Wnt-independent mechanism regulates cardiomyocyte growth](https://scholariq.org/papers/stabilization-of-catenin-by-a-wnt-independent-mechanism-regulates-cardiomyocyte/)

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Source: ScholarIQ — public research metadata, principally OpenAlex. See https://scholariq.org/sources/ for provenance and https://scholariq.org/methodology/ for what these figures mean.