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Journal of Medicinal Chemistry
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Journal of Medicinal Chemistry is a journal indexed in ScholarIQ from OpenAlex.
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(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes
Dooseop Kim, Liping Wang, Maria Beconi, George J. Eiermann, Michael H. Fisher, Huaibing He, Gerard J. Hickey, Jennifer E. Kowalchick, Barbara Leiting, Kathryn A. Lyons, Frank Marsilio, Margaret E. McCann, Reshma A. Patel, Aleksandr Petrov, Giovanna Scapin, Sangita B. Patel, Ranabir Sinha Roy, Joseph K. Wu, Matthew J. Wyvratt, Bei B. Zhang, Lan Zhu, Nancy A. Thornberry, Ann E. Weber
Discovery of a First-in-Class Receptor Interacting Protein 1 (RIP1) Kinase Specific Clinical Candidate (GSK2982772) for the Treatment of Inflammatory Diseases
Philip A. Harris, Scott B. Berger, Jae Uk Jeong, Rakesh Nagilla, Deepak Bandyopadhyay, Nino Campobasso, Carol A. Capriotti, Julie A. Cox, Lauren Dare, Xiaoyang Dong, Patrick M. Eidam, Joshua N. Finger, Sandra J. Hoffman, James Kang, Viera Kasparcova, Bryan W. King, Ruth Lehr, Yunfeng Lan, Lara K. Leister, John D. Lich, Thomas T. MacDonald, Nathan A. Miller, Michael T. Ouellette, Christina Pao, A. H. ABD EL RAHMAN, Michael Reilly, Alan R. Rendina, Elizabeth J. Rivera, Michelle C. Schaeffer, Clark A. Sehon, Robert R. Singhaus, Helen H. Sun, Barbara A. Swift, Rachel D. Totoritis, Anna Vossenkämper, Paris Ward, David D. Wisnoski, Daohua Zhang, Robert W. Marquis, Peter J. Gough, John Bertin
Synthesis, Structure–Activity Relationships, and in Vivo Efficacy of the Novel Potent and Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor 5-Chloro-<i>N</i>2-(2-isopropoxy-5-methyl-4-(piperidin-4-yl)phenyl)-<i>N</i>4-(2-(isopropylsulfonyl)phenyl)pyrimidine-2,4-diamine (LDK378) Currently in Phase 1 and Phase 2 Clinical Trials
Thomas H. Marsilje, Wei Pei, Bei Chen, Wenshuo Lu, Tetsuo Uno, Yunho Jin, Tao Jiang, Sung Joon Kim, Nanxin Li, Markus Warmuth, Yelena Sarkisova, Frank F. Sun, Auzon Steffy, AnneMarie Culazzo Pferdekamper, Allen G. Li, Sean B. Joseph, Young Ho Kim, Bo Liu, Tove Tuntland, Xiaoming Cui, Nathanael S. Gray, Ruo W. Steensma, Yongqin Wan, Jiqing Jiang, Greg Chopiuk, Jie Li, W. Perry Gordon, Wendy Richmond, Kevin C. Johnson, Jonathan Chang, Todd Groessl, You-Qun He, Andrew Phimister, J. Alex Aycinena, Christian C. Lee, Badry Bursulaya, Donald S. Karanewsky, H. Martin Seidel, Jennifer L. Harris, Pierre‐Yves Michellys
Discovery of Alogliptin: A Potent, Selective, Bioavailable, and Efficacious Inhibitor of Dipeptidyl Peptidase IV
Jun Feng, Zhiyuan Zhang, Michael B. Wallace, Jeffrey A. Stafford, Stephen W. Kaldor, Daniel B. Kassel, Marc Navre, Lihong Shi, R.J. Skene, Tomoko Asakawa, Koji Takeuchi, Rongda Xu, David R. Webb, Stephen L. Gwaltney
Novel Inhibitors of DNA Gyrase: 3D Structure Based Biased Needle Screening, Hit Validation by Biophysical Methods, and 3D Guided Optimization. A Promising Alternative to Random Screening
Hans-Joachim Boehm, Markus Boehringer, Daniel Bur, Hans Gmuender, Walter Huber, Werner Klaus, Dirk Kostrewa, Holger Kuehne, Thomas Luebbers, Nathalie Meunier-Keller, Francis Mueller