Papers.

• Epilepsy in adults 2,149 citations
• Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response 2,148 citations
• Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS) 2,148 citations
• 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension 2,148 citations
• Prevalence of chronic kidney disease in China: a cross-sectional survey 2,147 citations
• The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation 2,147 citations
• The Global Burden of Cardiovascular Diseases and Risk 2,147 citations
• Statistical Methods for Examining Heterogeneity and Combining Results from Several Studies in Meta‐Analysis 2,146 citations
• Gate-tuning of graphene plasmons revealed by infrared nano-imaging 2,146 citations
• Effectiveness-Based Guidelines for the Prevention of Cardiovascular Disease in Women—2011 Update 2,143 citations
• Ethical authorship and publishing 2,143 citations
• Phase III Trial of Nanoparticle Albumin-Bound Paclitaxel Compared With Polyethylated Castor Oil–Based Paclitaxel in Women With Breast Cancer 2,143 citations
• Multicenter Analysis of Glucocerebrosidase Mutations in Parkinson's Disease 2,142 citations
• Clarifying the concept of product–service system 2,141 citations
• Prognostic Factors for Overall Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Agents: Results From a Large, Multicenter Study 2,140 citations
• Online dictionary learning for sparse coding 2,139 citations
• Global Mapping of the Yeast Genetic Interaction Network 2,139 citations
• Metabolite profiling for plant functional genomics 2,137 citations
• Improving plant drought, salt, and freezing tolerance by gene transfer of a single stress-inducible transcription factor 2,137 citations
• El escorial World Federation of Neurology criteria for the diagnosis of amyotrophic lateral sclerosis 2,137 citations
• Structure and interactions in covalently and ionically crosslinked chitosan hydrogels for biomedical applications 2,135 citations
• Echocardiographic Assessment of Valve Stenosis: EAE/ASE Recommendations for Clinical Practice 2,135 citations
• Durable Complete Responses in Heavily Pretreated Patients with Metastatic Melanoma Using T-Cell Transfer Immunotherapy 2,135 citations
• For better or for worse: neural systems supporting the cognitive down- and up-regulation of negative emotion 2,132 citations
• Characteristics, drivers and feedbacks of global greening 2,131 citations
• Atypical Subtrochanteric and Diaphyseal Femoral Fractures: Second Report of a Task Force of the American Society for Bone and Mineral Research 2,128 citations
• Diagnostic Performance of 64-Multidetector Row Coronary Computed Tomographic Angiography for Evaluation of Coronary Artery Stenosis in Individuals Without Known Coronary Artery Disease 2,127 citations
• AZD9291 in EGFR Inhibitor–Resistant Non–Small-Cell Lung Cancer 2,126 citations
• Evolution of genes and genomes on the Drosophila phylogeny 2,126 citations
• Epidemiology of gastric cancer 2,123 citations
• Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update 2,123 citations
• The Triple Negative Paradox: Primary Tumor Chemosensitivity of Breast Cancer Subtypes 2,122 citations
• Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes 2,122 citations
• An active and socially integrated lifestyle in late life might protect against dementia 2,119 citations
• Defining the role of common variation in the genomic and biological architecture of adult human height 2,118 citations
• TRY plant trait database – enhanced coverage and open access 2,118 citations
• A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains 2,117 citations
• Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE) 2,117 citations
• Comparison of Early Invasive and Conservative Strategies in Patients with Unstable Coronary Syndromes Treated with the Glycoprotein IIb/IIIa Inhibitor Tirofiban 2,117 citations
• MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation 2,116 citations
• Adverse childhood experiences, allostasis, allostatic load, and age-related disease 2,115 citations
• 2011 ACCF/AHA Guideline for the Diagnosis and Treatment of Hypertrophic Cardiomyopathy 2,115 citations
• A Multicenter, Randomized Trial of Treatment for Mild Gestational Diabetes 2,114 citations
• AHA/ACC Guidelines for Secondary Prevention for Patients With Coronary and Other Atherosclerotic Vascular Disease: 2006 Update 2,114 citations
• Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance 2,112 citations
• Ultrafine particulate pollutants induce oxidative stress and mitochondrial damage. 2,112 citations
• Copper, iron and zinc in Alzheimer's disease senile plaques 2,112 citations
• A Critical Appraisal of the Quality of Quality-of-Life Measurements 2,111 citations
• Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature 2,111 citations
• Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study 2,109 citations
• Nervous system involvement after infection with COVID-19 and other coronaviruses 2,108 citations
• Physical Activity and Public Health in Older Adults 2,107 citations
• Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: the Eastern Cooperative Oncology Group Trial EST 1684. 2,106 citations
• A review of lithium-ion battery safety concerns: The issues, strategies, and testing standards 2,106 citations
• Normalization of Hemoglobin Level in Patients with Chronic Kidney Disease and Anemia 2,104 citations
• The revised two‐factor Study Process Questionnaire: R‐SPQ‐2F 2,103 citations
• Treating rheumatoid arthritis to target: recommendations of an international task force 2,102 citations
• 2013 ACCF/AHA Guideline for the Management of Heart Failure 2,102 citations
• Burnout and Medical Errors Among American Surgeons 2,100 citations
• Tracking restoration in natural and urban field settings 2,100 citations
• Effects of COVID-19 Home Confinement on Eating Behaviour and Physical Activity: Results of the ECLB-COVID19 International Online Survey 2,100 citations
• Subclinical Atrial Fibrillation and the Risk of Stroke 2,099 citations
• Integrated Genomic Characterization of Pancreatic Ductal Adenocarcinoma 2,099 citations
• Reporting Recommendations for Tumor Marker Prognostic Studies (REMARK) 2,098 citations
• Calcitonin gene-related peptide is a potent vasodilator 2,095 citations
• Description and evaluation of the Model for Ozone and Related chemical Tracers, version 4 (MOZART-4) 2,095 citations
• Lenvatinib versus Placebo in Radioiodine-Refractory Thyroid Cancer 2,094 citations
• Durable Clinical Benefit With Nivolumab Plus Ipilimumab in DNA Mismatch Repair–Deficient/Microsatellite Instability–High Metastatic Colorectal Cancer 2,094 citations
• Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease 2,093 citations
• Participation in Cancer Clinical Trials 2,092 citations
• The Genome Sequence of the SARS-Associated Coronavirus 2,089 citations
• A Trial of Darbepoetin Alfa in Type 2 Diabetes and Chronic Kidney Disease 2,088 citations
• Defining T Cell States Associated with Response to Checkpoint Immunotherapy in Melanoma 2,087 citations
• Sampling Variability of Liver Biopsy in Nonalcoholic Fatty Liver Disease 2,085 citations
• Plant phenology and global climate change: Current progresses and challenges 2,085 citations
• Eosinophilic esophagitis: Updated consensus recommendations for children and adults 2,083 citations
• Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS^®) Society Recommendations: 2018 2,082 citations
• Intellectual Impairment in Children with Blood Lead Concentrations below 10 μg per Deciliter 2,081 citations
• GRIPP2 reporting checklists: tools to improve reporting of patient and public involvement in research 2,081 citations
• Estimates of the prevalence of arthritis and other rheumatic conditions in the United States: Part I 2,081 citations
• Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk 2,080 citations
• Near-infrared fluorescent type II quantum dots for sentinel lymph node mapping 2,079 citations
• Practice Parameters for the Indications for Polysomnography and Related Procedures: An Update for 2005 2,079 citations
• Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial 2,079 citations
• Benazepril plus Amlodipine or Hydrochlorothiazide for Hypertension in High-Risk Patients 2,077 citations
• CPAP for Prevention of Cardiovascular Events in Obstructive Sleep Apnea 2,075 citations
• 70-Gene Signature as an Aid to Treatment Decisions in Early-Stage Breast Cancer 2,075 citations
• Frequent pathway mutations of splicing machinery in myelodysplasia 2,074 citations
• Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015 2,074 citations
• ACC/AHA 2008 Guidelines for the Management of Adults With Congenital Heart Disease: Executive Summary 2,072 citations
• Oncogenic Kras Maintains Pancreatic Tumors through Regulation of Anabolic Glucose Metabolism 2,071 citations
• Efficacy and safety of belimumab in patients with active systemic lupus erythematosus: a randomised, placebo-controlled, phase 3 trial 2,071 citations
• Grand challenges in global mental health 2,071 citations
• Technology-Enhanced Simulation for Health Professions Education 2,070 citations
• Olaparib plus Bevacizumab as First-Line Maintenance in Ovarian Cancer 2,070 citations
• The Metabolic Syndrome 2,068 citations
• Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency 2,068 citations
• 3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) 2,068 citations
• An improved framework for confound regression and filtering for control of motion artifact in the preprocessing of resting-state functional connectivity data 2,067 citations
• Two Phase 3 Trials of Dupilumab versus Placebo in Atopic Dermatitis 2,067 citations
• Reproducible brain-wide association studies require thousands of individuals 2,067 citations
• The results of direct and indirect treatment comparisons in meta-analysis of randomized controlled trials 2,066 citations
• Validation of the Mini Nutritional Assessment short-form (MNA®-SF): A practical tool for identification of nutritional status 2,066 citations
• Consolidated Health Economic Evaluation Reporting Standards (CHEERS)—Explanation and Elaboration: A Report of the ISPOR Health Economic Evaluation Publication Guidelines Good Reporting Practices Task Force 2,066 citations
• Prebiotic effects: metabolic and health benefits 2,066 citations
• Integrated Genomic and Proteomic Analyses of a Systematically Perturbed Metabolic Network 2,066 citations
• Sex Differences in the Gut Microbiome Drive Hormone-Dependent Regulation of Autoimmunity 2,065 citations
• Functional impact of global rare copy number variation in autism spectrum disorders 2,064 citations
• Hundreds of variants clustered in genomic loci and biological pathways affect human height 2,063 citations
• DNA-Binding Specificity of the ERF/AP2 Domain of Arabidopsis DREBs, Transcription Factors Involved in Dehydration- and Cold-Inducible Gene Expression 2,062 citations
• Conjoint Analysis Applications in Health—a Checklist: A Report of the ISPOR Good Research Practices for Conjoint Analysis Task Force 2,061 citations
• Synthesising qualitative and quantitative evidence: A review of possible methods 2,059 citations
• Phase III Trial of Carboplatin and Paclitaxel Compared With Cisplatin and Paclitaxel in Patients With Optimally Resected Stage III Ovarian Cancer: A Gynecologic Oncology Group Study 2,059 citations
• Enabling the implementation of evidence based practice: a conceptual framework. 2,058 citations
• Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor 2,058 citations
• Efficacy and safety of a paired sedation and ventilator weaning protocol for mechanically ventilated patients in intensive care (Awakening and Breathing Controlled trial): a randomised controlled trial 2,058 citations
• Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life Years for 29 Cancer Groups From 2010 to 2019 2,058 citations
• Tau Suppression in a Neurodegenerative Mouse Model Improves Memory Function 2,057 citations
• European guideline for the diagnosis and treatment of insomnia 2,057 citations
• Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study 2,057 citations
• Pollution and health: a progress update 2,057 citations
• Planned caesarean section versus planned vaginal birth for breech presentation at term: a randomised multicentre trial 2,056 citations
• Method for analysis of cellular DNA content of paraffin-embedded pathological material using flow cytometry. 2,055 citations
• Genomewide Association Analysis of Coronary Artery Disease 2,055 citations
• American Society of Clinical Oncology Recommendations on Fertility Preservation in Cancer Patients 2,054 citations
• Association of Trypanolytic ApoL1 Variants with Kidney Disease in African Americans 2,053 citations
• Patient safety, satisfaction, and quality of hospital care: cross sectional surveys of nurses and patients in 12 countries in Europe and the United States 2,053 citations
• Re-examining the Unified Theory of Acceptance and Use of Technology (UTAUT): Towards a Revised Theoretical Model 2,053 citations
• The Global Health and Economic Burden of Hospitalizations for Heart Failure 2,053 citations
• The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screening 2,052 citations
• Guidelines for the diagnosis and management of syncope (version 2009): The Task Force for the Diagnosis and Management of Syncope of the European Society of Cardiology (ESC) 2,052 citations
• The COVID-19 pandemic and health inequalities 2,051 citations
• Long-Term Follow-Up of Patients With Mild Coronary Artery Disease and Endothelial Dysfunction 2,049 citations
• International Consensus on Use of Continuous Glucose Monitoring 2,049 citations
• Analysis of shared heritability in common disorders of the brain 2,047 citations
• Prevalence, Incidence, and Mortality of Stroke in China 2,047 citations
• The Genome Sequence of the Malaria Mosquito <i>Anopheles gambiae</i> 2,046 citations
• Correct Homeostasis Model Assessment (HOMA) Evaluation Uses the Computer Program 2,044 citations
• CONSORT-EHEALTH: Improving and Standardizing Evaluation Reports of Web-based and Mobile Health Interventions 2,044 citations
• Effects of Dalcetrapib in Patients with a Recent Acute Coronary Syndrome 2,044 citations
• The Long-Term Effect of Doxazosin, Finasteride, and Combination Therapy on the Clinical Progression of Benign Prostatic Hyperplasia 2,044 citations
• Burnout Among U.S. Medical Students, Residents, and Early Career Physicians Relative to the General U.S. Population 2,044 citations
• International Consensus Guidelines for Management of Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms of the Pancreas 2,043 citations
• Predicting survival after liver transplantation in patients with hepatocellular carcinoma beyond the Milan criteria: a retrospective, exploratory analysis 2,043 citations
• Global prevalence and genotype distribution of hepatitis C virus infection in 2015: a modelling study 2,039 citations
• Hepatic encephalopathy—Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998 2,038 citations
• Ribociclib as First-Line Therapy for HR-Positive, Advanced Breast Cancer 2,037 citations
• Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway 2,037 citations
• Risk factors for coronary artery disease in non-insulin dependent diabetes mellitus: United Kingdom prospective diabetes study (UKPDS: 23) 2,036 citations
• The COMET Handbook: version 1.0 2,036 citations
• Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 2,035 citations
• The clonal and mutational evolution spectrum of primary triple-negative breast cancers 2,034 citations
• HIF-1α Is Essential for Myeloid Cell-Mediated Inflammation 2,034 citations
• Rosuvastatin and Cardiovascular Events in Patients Undergoing Hemodialysis 2,033 citations
• Burden of Gastrointestinal Disease in the United States: 2012 Update 2,032 citations
• 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus 2,032 citations
• The Seattle Heart Failure Model 2,031 citations
• Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 2,031 citations
• Effectiveness of convalescent plasma therapy in severe COVID-19 patients 2,031 citations
• The Sentinel Node in Breast Cancer — A Multicenter Validation Study 2,030 citations
• Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals 2,029 citations
• Declaración PRISMA 2020: una guía actualizada para la publicación de revisiones sistemáticas 2,028 citations
• Reflections on Past Behavior: A Self‐Report Index of Habit Strength¹ 2,027 citations
• AACR Project GENIE: Powering Precision Medicine through an International Consortium 2,027 citations
• Guidelines on the prevention, diagnosis, and treatment of infective endocarditis (new version 2009): The Task Force on the Prevention, Diagnosis, and Treatment of Infective Endocarditis of the European Society of Cardiology (ESC) 2,026 citations
• Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease 2,024 citations
• Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes 2,024 citations
• Diabetes in Asia 2,024 citations
• Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines—2016 revision 2,024 citations
• Standard-dose versus high-dose conformal radiotherapy with concurrent and consolidation carboplatin plus paclitaxel with or without cetuximab for patients with stage IIIA or IIIB non-small-cell lung cancer (RTOG 0617): a randomised, two-by-two factorial phase 3 study 2,022 citations
• Global, regional, and national disability-adjusted life years (DALYs) for 306 diseases and injuries and healthy life expectancy (HALE) for 188 countries, 1990–2013: quantifying the epidemiological transition 2,022 citations
• Management of Hyperglycemia in Type 2 Diabetes, 2022. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) 2,022 citations
• Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease 2,020 citations
• Development of physical and mental health summary scores from the patient-reported outcomes measurement information system (PROMIS) global items 2,020 citations
• A novel cis-acting element in an Arabidopsis gene is involved in responsiveness to drought, low-temperature, or high-salt stress. 2,019 citations
• All-inorganic perovskite nanocrystal scintillators 2,018 citations
• Antidepressant Drug Effects and Depression Severity 2,017 citations
• AASLD guidelines for treatment of chronic hepatitis B 2,017 citations
• A new taxonomy for describing and defining adherence to medications 2,016 citations
• Global, regional, and national burden of traumatic brain injury and spinal cord injury, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 2,016 citations
• Lazy, not biased: Susceptibility to partisan fake news is better explained by lack of reasoning than by motivated reasoning 2,016 citations
• Effect of angiotensin-converting-enzyme inhibition compared with conventional therapy on cardiovascular morbidity and mortality in hypertension: the Captopril Prevention Project (CAPPP) randomised trial 2,015 citations
• Guidelines on the management of valvular heart disease (version 2012) 2,015 citations
• Clinical Factors Associated With Calcific Aortic Valve Disease 2,014 citations
• Functional Connectivity: The Principal-Component Analysis of Large (PET) Data Sets 2,013 citations
• Clinical Practice Guideline: Otitis Media with Effusion (Update) 2,011 citations
• Flavonoids: antioxidants or signalling molecules? 2,010 citations
• Optimal cut-off score for diagnosing depression with the Patient Health Questionnaire (PHQ-9): a meta-analysis 2,010 citations
• Coordinate‐based activation likelihood estimation meta‐analysis of neuroimaging data: A random‐effects approach based on empirical estimates of spatial uncertainty 2,008 citations
• Assessment of Ki67 in Breast Cancer: Recommendations from the International Ki67 in Breast Cancer Working Group 2,007 citations
• FGF23 induces left ventricular hypertrophy 2,006 citations
• The Classification of Glomerulonephritis in Systemic Lupus Erythematosus Revisited 2,006 citations
• Modifiable risk factors, cardiovascular disease, and mortality in 155 722 individuals from 21 high-income, middle-income, and low-income countries (PURE): a prospective cohort study 2,005 citations
• Prostate-specific membrane antigen PET-CT in patients with high-risk prostate cancer before curative-intent surgery or radiotherapy (proPSMA): a prospective, randomised, multicentre study 2,004 citations
• The Emerging Evidence of the Parkinson Pandemic 2,003 citations
• Crizotinib in <i>ROS1</i>-Rearranged Non–Small-Cell Lung Cancer 2,002 citations
• A dual-networks architecture of top-down control 2,002 citations
• A Comparison of Immediate Angioplasty with Thrombolytic Therapy for Acute Myocardial Infarction 2,002 citations
• The neural and computational bases of semantic cognition 2,002 citations
• Deep Learning for Health Informatics 2,002 citations

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