Papers.

• Heart Disease and Stroke Statistics—2014 Update 5,233 citations
• The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis 5,219 citations
• Decoding tumour phenotype by noninvasive imaging using a quantitative radiomics approach 5,209 citations
• The Somatic Genomic Landscape of Glioblastoma 5,205 citations
• Guidelines for the Prevention of Stroke in Patients With Stroke and Transient Ischemic Attack 5,201 citations
• Optimism, coping, and health: Assessment and implications of generalized outcome expectancies. 5,197 citations
• CDC Guideline for Prescribing Opioids for Chronic Pain—United States, 2016 5,192 citations
• Heart Disease and Stroke Statistics—2013 Update 5,190 citations
• Association of Anxiety-Related Traits with a Polymorphism in the Serotonin Transporter Gene Regulatory Region 5,190 citations
• Natural products in drug discovery: advances and opportunities 5,183 citations
• Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021 5,178 citations
• The Patient-Reported Outcomes Measurement Information System (PROMIS) developed and tested its first wave of adult self-reported health outcome item banks: 2005–2008 5,172 citations
• Classification of primary progressive aphasia and its variants 5,169 citations
• Edoxaban versus Warfarin in Patients with Atrial Fibrillation 5,162 citations
• Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies 5,157 citations
• Proposed minimum reporting standards for chemical analysis 5,154 citations
• Use and Abuse of HOMA Modeling 5,146 citations
• Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials 5,145 citations
• Standardised Nordic questionnaires for the analysis of musculoskeletal symptoms 5,127 citations
• Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck 5,125 citations
• Cardiovascular and Renal Outcomes with Empagliflozin in Heart Failure 5,122 citations
• Trastuzumab after Adjuvant Chemotherapy in HER2-Positive Breast Cancer 5,111 citations
• Assessment of eating disorders: Interview or self‐report questionnaire? 5,108 citations
• External review and validation of the Swedish national inpatient register 5,108 citations
• Possible selves. 5,105 citations
• The Lifelong Effects of Early Childhood Adversity and Toxic Stress 5,102 citations
• <i>Conn</i> : A Functional Connectivity Toolbox for Correlated and Anticorrelated Brain Networks 5,101 citations
• 2020 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation 5,095 citations
• Reactive oxygen species (ROS) as pleiotropic physiological signalling agents 5,092 citations
• Using social and behavioural science to support COVID-19 pandemic response 5,091 citations
• Frontotemporal lobar degeneration 5,083 citations
• Diagnosis and management of dementia with Lewy bodies 5,072 citations
• Post-acute COVID-19 syndrome 5,067 citations
• Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 5,058 citations
• The PRISMA 2020 statement: An updated guideline for reporting systematic reviews 5,052 citations
• Dysregulation of Immune Response in Patients With Coronavirus 2019 (COVID-19) in Wuhan, China 5,043 citations
• Parkinson disease 5,041 citations
• The Scenario Model Intercomparison Project (ScenarioMIP) for CMIP6 5,040 citations
• Mendelian randomization: Using genes as instruments for making causal inferences in epidemiology 5,033 citations
• Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK 5,024 citations
• Comparison of the efficacy and safety of new oral anticoagulants with warfarin in patients with atrial fibrillation: a meta-analysis of randomised trials 5,014 citations
• Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS 5,010 citations
• Deep visual-semantic alignments for generating image descriptions 5,006 citations
• 2015 ESC Guidelines for the management of infective endocarditis 5,003 citations
• Mild cognitive impairment – beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment 4,994 citations
• The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism 4,980 citations
• 2013 ACC/AHA Guideline on the Assessment of Cardiovascular Risk 4,978 citations
• Determining cell type abundance and expression from bulk tissues with digital cytometry 4,977 citations
• Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis 4,966 citations
• Measurement of health status 4,961 citations
• A Model to Predict Survival in Patients With End–Stage Liver Disease 4,960 citations
• Intensive versus Moderate Lipid Lowering with Statins after Acute Coronary Syndromes 4,953 citations
• Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked 4,952 citations
• Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016: a systematic analysis for the Global Burden of Disease Study 2016 4,950 citations
• <scp>ILAE</scp> classification of the epilepsies: Position paper of the <scp>ILAE</scp> Commission for Classification and Terminology 4,949 citations
• Genetic studies of body mass index yield new insights for obesity biology 4,948 citations
• The global prevalence of dementia: A systematic review and metaanalysis 4,946 citations
• 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative 4,932 citations
• Eplerenone, a Selective Aldosterone Blocker, in Patients with Left Ventricular Dysfunction after Myocardial Infarction 4,932 citations
• The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity 4,926 citations
• Oxidative Stress and Antioxidant Defense 4,925 citations
• Prevalence of Chronic Kidney Disease in the United States 4,918 citations
• Vascular dementia 4,916 citations
• 2019 ESC Guidelines on diabetes, pre-diabetes, and cardiovascular diseases developed in collaboration with the EASD 4,910 citations
• Host–microbe interactions have shaped the genetic architecture of inflammatory bowel disease 4,908 citations
• Optimism, coping, and health: Assessment and implications of generalized outcome expectancies. 4,892 citations
• 2019 ESC Guidelines for the diagnosis and management of acute pulmonary embolism developed in collaboration with the European Respiratory Society (ERS) 4,882 citations
• 2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk 4,881 citations
• Global Biodiversity: Indicators of Recent Declines 4,880 citations
• The Lancet Commission on pollution and health 4,877 citations
• International Association for the Study of Lung Cancer/American Thoracic Society/European Respiratory Society International Multidisciplinary Classification of Lung Adenocarcinoma 4,866 citations
• A Cyber-Physical Systems architecture for Industry 4.0-based manufacturing systems 4,865 citations
• Role of Genotype in the Cycle of Violence in Maltreated Children 4,862 citations
• A gradient of childhood self-control predicts health, wealth, and public safety 4,860 citations
• Evolution of Organic Aerosols in the Atmosphere 4,858 citations
• Validation of Clinical Classification Schemes for Predicting Stroke 4,850 citations
• The Danish National Patient Registry: a review of content, data quality, and research potential 4,832 citations
• Anxiety Disorders in Primary Care: Prevalence, Impairment, Comorbidity, and Detection 4,829 citations
• Defining and Setting National Goals for Cardiovascular Health Promotion and Disease Reduction 4,822 citations
• Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38 4,820 citations
• Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients 4,817 citations
• 2023 ESC Guidelines for the management of acute coronary syndromes 4,817 citations
• Exercise training increases size of hippocampus and improves memory 4,800 citations
• Reliability of the PEDro Scale for Rating Quality of Randomized Controlled Trials 4,796 citations
• Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial 4,795 citations
• Glucose Control and Vascular Complications in Veterans with Type 2 Diabetes 4,791 citations
• Persistent Symptoms in Patients After Acute COVID-19 4,786 citations
• Identifying Medical Diagnoses and Treatable Diseases by Image-Based Deep Learning 4,785 citations
• Immune-Related Adverse Events Associated with Immune Checkpoint Blockade 4,775 citations
• Fingerprints of global warming on wild animals and plants 4,773 citations
• Non-invasive detection of endothelial dysfunction in children and adults at risk of atherosclerosis 4,769 citations
• Cognitive Therapy of Depression 4,766 citations
• Pathological complete response and long-term clinical benefit in breast cancer: the CTNeoBC pooled analysis 4,765 citations
• Once-Weekly Semaglutide in Adults with Overweight or Obesity 4,748 citations
• 2013 ACCF/AHA Guideline for the Management of ST-Elevation Myocardial Infarction 4,731 citations
• Allergic Rhinitis and its Impact on Asthma (ARIA) 2008* 4,730 citations
• Artificial intelligence in healthcare: past, present and future 4,719 citations
• Empagliflozin in Heart Failure with a Preserved Ejection Fraction 4,718 citations
• Optimal Medical Therapy with or without PCI for Stable Coronary Disease 4,706 citations
• The IASLC Lung Cancer Staging Project: Proposals for Revision of the TNM Stage Groupings in the Forthcoming (Eighth) Edition of the TNM Classification for Lung Cancer 4,703 citations
• Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease 4,699 citations
• Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 countries and territories and 811 subnational locations, 1990–2021: a systematic analysis for the Global Burden of Disease Study 2021 4,697 citations
• Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma 4,691 citations
• Temporal dynamics in viral shedding and transmissibility of COVID-19 4,690 citations
• The Effect of Carvedilol on Morbidity and Mortality in Patients with Chronic Heart Failure 4,679 citations
• Screening λgt Recombinant Clones by Hybridization to Single Plaques in Situ 4,664 citations
• Stated choice methods analysis and applications 4,651 citations
• Effects of Bariatric Surgery on Mortality in Swedish Obese Subjects 4,645 citations
• What low back pain is and why we need to pay attention 4,645 citations
• National Kidney Foundation Practice Guidelines for Chronic Kidney Disease: Evaluation, Classification, and Stratification 4,636 citations
• Genome sequence of the palaeopolyploid soybean 4,629 citations
• A Voxel-Based Morphometric Study of Ageing in 465 Normal Adult Human Brains 4,611 citations
• Applied Multiple Regression/Correlation Analysis for the Behavioral Sciences. 4,611 citations
• A second generation human haplotype map of over 3.1 million SNPs 4,605 citations
• Cancer patients in SARS-CoV-2 infection: a nationwide analysis in China 4,605 citations
• International consensus diagnostic criteria for neuromyelitis optica spectrum disorders 4,604 citations
• Increased Survival with Enzalutamide in Prostate Cancer after Chemotherapy 4,604 citations
• Histone H3K27ac separates active from poised enhancers and predicts developmental state 4,597 citations
• Circular RNAs are abundant, conserved, and associated with ALU repeats 4,596 citations
• RNA velocity of single cells 4,595 citations
• Impact of Atrial Fibrillation on the Risk of Death 4,594 citations
• Cardiac Resynchronization in Chronic Heart Failure 4,593 citations
• A Draft Sequence of the Neandertal Genome 4,592 citations
• Durvalumab after Chemoradiotherapy in Stage III Non–Small-Cell Lung Cancer 4,592 citations
• Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery 4,589 citations
• From best evidence to best practice: effective implementation of change in patients' care 4,589 citations
• Derivation of the sledai. A disease activity index for lupus patients 4,588 citations
• Final Version of 2009 AJCC Melanoma Staging and Classification 4,587 citations
• 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines 4,564 citations
• Association of Cardiac Injury With Mortality in Hospitalized Patients With COVID-19 in Wuhan, China 4,557 citations
• One Hundred Years After “Carcinoid”: Epidemiology of and Prognostic Factors for Neuroendocrine Tumors in 35,825 Cases in the United States 4,541 citations
• Functional profiling of the Saccharomyces cerevisiae genome 4,537 citations
• 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines 4,536 citations
• Endocrine-Disrupting Chemicals: An Endocrine Society Scientific Statement 4,533 citations
• A review on genetic algorithm: past, present, and future 4,521 citations
• ACC/AHA Guidelines for the Management of Patients With Unstable Angina and Non–ST-Segment Elevation Myocardial Infarction: Executive Summary and Recommendations 4,516 citations
• Anaplastic Lymphoma Kinase Inhibition in Non–Small-Cell Lung Cancer 4,513 citations
• Genome sequence of the human malaria parasite Plasmodium falciparum 4,502 citations
• A Common Variant in the <i>FTO</i> Gene Is Associated with Body Mass Index and Predisposes to Childhood and Adult Obesity 4,502 citations
• A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD 4,500 citations
• A point‐charge force field for molecular mechanics simulations of proteins based on condensed‐phase quantum mechanical calculations 4,494 citations
• Gain-of-Function Mutations of c- <i>kit</i> in Human Gastrointestinal Stromal Tumors 4,494 citations
• Perfluoroalkyl and polyfluoroalkyl substances in the environment: Terminology, classification, and origins 4,485 citations
• A simple method for clinical assay of superoxide dismutase. 4,485 citations
• 2014 ESC Guidelines on the diagnosis and treatment of aortic diseases 4,480 citations
• A nationwide survey of psychological distress among Chinese people in the COVID‐19 epidemic: implications and policy recommendations 4,479 citations
• <i>MET</i> Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling 4,477 citations
• Ipilimumab plus Dacarbazine for Previously Untreated Metastatic Melanoma 4,477 citations
• A clinical approach to diagnosis of autoimmune encephalitis 4,477 citations
• The Genome of Black Cottonwood, <i>Populus trichocarpa</i> (Torr. &amp; Gray) 4,473 citations
• Lifestyle, Diabetes, and Cardiovascular Risk Factors 10 Years after Bariatric Surgery 4,472 citations
• Standardized Bleeding Definitions for Cardiovascular Clinical Trials 4,471 citations
• A new definition for metabolic dysfunction-associated fatty liver disease: An international expert consensus statement 4,467 citations
• Functional Network Organization of the Human Brain 4,454 citations
• Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes 4,452 citations
• Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021 4,448 citations
• Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis 4,445 citations
• Development of AMSTAR: a measurement tool to assess the methodological quality of systematic reviews 4,441 citations
• Proceedings of the National Academy of Sciences 4,437 citations
• Cancer treatment and survivorship statistics, 2019 4,429 citations
• The Alzheimer's disease neuroimaging initiative (ADNI): MRI methods 4,427 citations
• Identification and Importance of Brown Adipose Tissue in Adult Humans 4,423 citations
• Abiraterone and Increased Survival in Metastatic Prostate Cancer 4,422 citations
• Nutritional Epidemiology 4,422 citations
• Tumor mutational load predicts survival after immunotherapy across multiple cancer types 4,419 citations
• A review of correlates of physical activity of children and adolescents 4,416 citations
• Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis 4,414 citations
• Multifactorial Intervention and Cardiovascular Disease in Patients with Type 2 Diabetes 4,410 citations
• Worldwide trends in diabetes since 1980: a pooled analysis of 751 population-based studies with 4·4 million participants 4,408 citations
• Adherence to a Mediterranean Diet and Survival in a Greek Population 4,401 citations
• Research criteria for the diagnosis of Alzheimer's disease: revising the NINCDS–ADRDA criteria 4,397 citations
• Chronic kidney disease: global dimension and perspectives 4,393 citations
• Structural and functional features of central nervous system lymphatic vessels 4,385 citations
• Differential Diagnosis of Glomerular Disease: A Systematic and Inclusive Approach 4,380 citations
• Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography 4,380 citations
• Revised terminology and concepts for organization of seizures and epilepsies: Report of the ILAE Commission on Classification and Terminology, 2005–2009 4,372 citations
• National Sleep Foundation’s sleep time duration recommendations: methodology and results summary 4,357 citations
• EGF receptor gene mutations are common in lung cancers from “never smokers” and are associated with sensitivity of tumors to gefitinib and erlotinib 4,354 citations
• Cardiovascular Implications of Fatal Outcomes of Patients With Coronavirus Disease 2019 (COVID-19) 4,347 citations
• 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines 4,346 citations
• Guidelines for the Management of Severe Traumatic Brain Injury, Fourth Edition 4,343 citations
• REPRODUCIBILITY AND VALIDITY OF A SEMIQUANTITATIVE FOOD FREQUENCY QUESTIONNAIRE 4,337 citations
• 2014 ESC Guidelines on diagnosis and management of hypertrophic cardiomyopathy 4,336 citations
• fMRIPrep: a robust preprocessing pipeline for functional MRI 4,290 citations
• Life with 6000 Genes 4,273 citations
• A Draft Sequence of the Rice Genome ( <i>Oryza sativa</i> L. ssp. <i>indica</i> ) 4,270 citations
• Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1 4,257 citations
• Managing Innovation: Integrating Technological, Market and Organizational Change 4,245 citations
• A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data 4,244 citations
• Universal Definition of Myocardial Infarction 4,244 citations
• RETRACTED: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet 4,244 citations
• The B73 Maize Genome: Complexity, Diversity, and Dynamics 4,243 citations
• Fractional Flow Reserve versus Angiography for Guiding Percutaneous Coronary Intervention 4,240 citations
• The 2016 update of the International Study Group (ISGPS) definition and grading of postoperative pancreatic fistula: 11 Years After 4,239 citations
• Profiling Tumor Infiltrating Immune Cells with CIBERSORT 4,237 citations
• Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase 4,233 citations
• Sirolimus-Eluting Stents versus Standard Stents in Patients with Stenosis in a Native Coronary Artery 4,227 citations
• Preoperative Radiotherapy Combined with Total Mesorectal Excision for Resectable Rectal Cancer 4,226 citations
• Interactions Between the Microbiota and the Immune System 4,218 citations
• Trends in Prevalence and Outcome of Heart Failure with Preserved Ejection Fraction 4,215 citations

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