Papers.

• Distant metastasis occurs late during the genetic evolution of pancreatic cancer 2,537 citations
• Adjuvant Chemotherapy for Gastric Cancer with S-1, an Oral Fluoropyrimidine 2,536 citations
• Comprehensive Characterization of Cancer Driver Genes and Mutations 2,536 citations
• Screening for Colorectal Cancer 2,535 citations
• Universal definition of myocardial infarction: Kristian Thygesen, Joseph S. Alpert and Harvey D. White on behalf of the Joint ESC/ACCF/AHA/WHF Task Force for the Redefinition of Myocardial Infarction 2,534 citations
• The human endothelin family: three structurally and pharmacologically distinct isopeptides predicted by three separate genes. 2,532 citations
• Analysis of fMRI Time-Series Revisited 2,532 citations
• New insights into the genetic etiology of Alzheimer’s disease and related dementias 2,532 citations
• Effects of eicosapentaenoic acid on major coronary events in hypercholesterolaemic patients (JELIS): a randomised open-label, blinded endpoint analysis 2,531 citations
• [Effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes]. 2,531 citations
• Reduction and Functional Exhaustion of T Cells in Patients With Coronavirus Disease 2019 (COVID-19) 2,530 citations
• Tracking of childhood overweight into adulthood: a systematic review of the literature 2,528 citations
• Alogliptin after Acute Coronary Syndrome in Patients with Type 2 Diabetes 2,527 citations
• Part 9: Post–Cardiac Arrest Care 2,526 citations
• Prevention of disabling and fatal strokes by successful carotid endarterectomy in patients without recent neurological symptoms: randomised controlled trial 2,523 citations
• Clinical research criteria for the diagnosis of progressive supranuclear palsy (Steele-Richardson-Olszewski syndrome) 2,522 citations
• Setting the future of digital and social media marketing research: Perspectives and research propositions 2,520 citations
• Cholangiocarcinoma 2020: the next horizon in mechanisms and management 2,520 citations
• 2023 ESC Guidelines for the management of cardiomyopathies 2,519 citations
• What is e-health? 2,517 citations
• A Proposed Grading System for Arteriovenous Malformations 2,516 citations
• ESPEN guidelines on definitions and terminology of clinical nutrition 2,516 citations
• An official European Respiratory Society/American Thoracic Society technical standard: field walking tests in chronic respiratory disease 2,514 citations
• 2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management of Atrial Fibrillation: A Report of the American College of Cardiology/American Heart Association Joint Committee on Clinical Practice Guidelines 2,514 citations
• Psychiatric and neuropsychiatric presentations associated with severe coronavirus infections: a systematic review and meta-analysis with comparison to the COVID-19 pandemic 2,513 citations
• Transfusion of Plasma, Platelets, and Red Blood Cells in a 1:1:1 vs a 1:1:2 Ratio and Mortality in Patients With Severe Trauma 2,511 citations
• Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys 2,508 citations
• Cardiovascular Magnetic Resonance in Myocarditis: A JACC White Paper 2,508 citations
• Cyclooxygenase in biology and disease 2,508 citations
• Placebo-Controlled, Double-Blind, Prospective, Randomized Study on the Effect of Octreotide LAR in the Control of Tumor Growth in Patients With Metastatic Neuroendocrine Midgut Tumors: A Report From the PROMID Study Group 2,507 citations
• Potential for primary prevention of Alzheimer's disease: an analysis of population-based data 2,505 citations
• Global estimates of mortality associated with long-term exposure to outdoor fine particulate matter 2,504 citations
• Efficacy and Toxicity Management of 19-28z CAR T Cell Therapy in B Cell Acute Lymphoblastic Leukemia 2,503 citations
• Genetics of rheumatoid arthritis contributes to biology and drug discovery 2,501 citations
• Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors 2,501 citations
• Child and adolescent mental health worldwide: evidence for action 2,499 citations
• Artificial intelligence for decision making in the era of Big Data – evolution, challenges and research agenda 2,499 citations
• Type 2 diabetes 2,498 citations
• Analysis of Tumor Specimens at the Time of Acquired Resistance to EGFR-TKI Therapy in 155 Patients with <i>EGFR</i> -Mutant Lung Cancers 2,497 citations
• Rheumatoid arthritis 2,497 citations
• The p Factor 2,495 citations
• Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines 2016 for the treatment of colorectal cancer 2,494 citations
• Executive Summary: Heart Disease and Stroke Statistics—2016 Update 2,494 citations
• Nipype: A Flexible, Lightweight and Extensible Neuroimaging Data Processing Framework in Python 2,492 citations
• SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues 2,492 citations
• “Weathering” and Age Patterns of Allostatic Load Scores Among Blacks and Whites in the United States 2,491 citations
• Valsartan, Captopril, or Both in Myocardial Infarction Complicated by Heart Failure, Left Ventricular Dysfunction, or Both 2,490 citations
• Global, regional, and national burden of Alzheimer's disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 2,490 citations
• Short Sleep Duration Is Associated with Reduced Leptin, Elevated Ghrelin, and Increased Body Mass Index 2,489 citations
• Alectinib versus Crizotinib in Untreated <i>ALK</i>-Positive Non–Small-Cell Lung Cancer 2,489 citations
• Large-Scale Exome Sequencing Study Implicates Both Developmental and Functional Changes in the Neurobiology of Autism 2,488 citations
• Circulating Breast Tumor Cells Exhibit Dynamic Changes in Epithelial and Mesenchymal Composition 2,487 citations
• Ramucirumab plus paclitaxel versus placebo plus paclitaxel in patients with previously treated advanced gastric or gastro-oesophageal junction adenocarcinoma (RAINBOW): a double-blind, randomised phase 3 trial 2,486 citations
• Cytochrome P-450 Polymorphisms and Response to Clopidogrel 2,485 citations
• Amyotrophic lateral sclerosis 2,485 citations
• Nicotine replacement therapy for smoking cessation 2,484 citations
• Evidence-Based Recommendations for Optimal Dietary Protein Intake in Older People: A Position Paper From the PROT-AGE Study Group 2,483 citations
• Isolation and Characterization of Viruses Related to the SARS Coronavirus from Animals in Southern China 2,483 citations
• The Danish National Prescription Registry 2,483 citations
• An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: an observational cohort study 2,483 citations
• A Resilient, Low-Frequency, Small-World Human Brain Functional Network with Highly Connected Association Cortical Hubs 2,479 citations
• Anti-TNF Antibody Therapy in Rheumatoid Arthritis and the Risk of Serious Infections and Malignancies 2,479 citations
• COVID-19 and its implications for thrombosis and anticoagulation 2,479 citations
• Idecabtagene Vicleucel in Relapsed and Refractory Multiple Myeloma 2,479 citations
• Guidelines for the Early Management of Adults With Ischemic Stroke 2,478 citations
• Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030 2,477 citations
• The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial 2,477 citations
• Niraparib Maintenance Therapy in Platinum-Sensitive, Recurrent Ovarian Cancer 2,477 citations
• Analysis of therapeutic targets for SARS-CoV-2 and discovery of potential drugs by computational methods 2,477 citations
• KDIGO 2021 Clinical Practice Guideline for the Management of Glomerular Diseases 2,475 citations
• Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity: studies in subjects with various degrees of glucose tolerance and insulin sensitivity. 2,474 citations
• International Classification of Sleep Disorders 2,474 citations
• Targeting PI3K signalling in cancer: opportunities, challenges and limitations 2,466 citations
• C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction 2,466 citations
• Calculation of pressure fields from arbitrarily shaped, apodized, and excited ultrasound transducers 2,466 citations
• A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2 2,465 citations
• Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 2,463 citations
• A lexicon for endoscopic adverse events: report of an ASGE workshop 2,462 citations
• Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial 2,462 citations
• Genomic atlas of the human plasma proteome 2,462 citations
• Extensions of net reclassification improvement calculations to measure usefulness of new biomarkers 2,457 citations
• Statins and risk of incident diabetes: a collaborative meta-analysis of randomised statin trials 2,456 citations
• Prevention and treatment of low back pain: evidence, challenges, and promising directions 2,456 citations
• Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality—a systematic review and dose-response meta-analysis of prospective studies 2,455 citations
• PhenoScanner V2: an expanded tool for searching human genotype–phenotype associations 2,451 citations
• Cloning of the Gene Containing Mutations that Cause PARK8-Linked Parkinson's Disease 2,449 citations
• Hepatogastroenterology 2,449 citations
• KDOQI Clinical Practice Guideline for Vascular Access: 2019 Update 2,449 citations
• 2. Classification and Diagnosis of Diabetes:<i>Standards of Care in Diabetes—2023</i> 2,449 citations
• Cachexia: A new definition 2,448 citations
• Global Burden of Hypertension and Systolic Blood Pressure of at Least 110 to 115 mm Hg, 1990-2015 2,448 citations
• The human tumor microbiome is composed of tumor type–specific intracellular bacteria 2,447 citations
• A Simple Proof of the Restricted Isometry Property for Random Matrices 2,446 citations
• Parameterizing neural power spectra into periodic and aperiodic components 2,442 citations
• Computational procedures for probing interactions in OLS and logistic regression: SPSS and SAS implementations 2,441 citations
• Cloning of a cDNA encoding a non-isopeptide-selective subtype of the endothelin receptor 2,439 citations
• Systematic review of COVID‐19 in children shows milder cases and a better prognosis than adults 2,439 citations
• A cross-population atlas of genetic associations for 220 human phenotypes 2,437 citations
• The anti-inflammatory effects of exercise: mechanisms and implications for the prevention and treatment of disease 2,436 citations
• Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy 2,436 citations
• The complete nucleotide sequence of the tobacco chloroplast genome: its gene organization and expression 2,436 citations
• SANRA—a scale for the quality assessment of narrative review articles 2,436 citations
• Tutorial in biostatistics: competing risks and multi‐state models 2,435 citations
• Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease 2,434 citations
• Childhood Adversities Increase the Risk of Psychosis: A Meta-analysis of Patient-Control, Prospective- and Cross-sectional Cohort Studies 2,432 citations
• Establishing a causal chain: Why experiments are often more effective than mediational analyses in examining psychological processes. 2,432 citations
• Association of psychosocial risk factors with risk of acute myocardial infarction in 11 119 cases and 13 648 controls from 52 countries (the INTERHEART study): case-control study 2,431 citations
• Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial 2,429 citations
• International network of cancer genome projects 2,426 citations
• Initial Invasive or Conservative Strategy for Stable Coronary Disease 2,426 citations
• Treatment of 5 Critically Ill Patients With COVID-19 With Convalescent Plasma 2,425 citations
• Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup 2,424 citations
• The Swedish personal identity number: possibilities and pitfalls in healthcare and medical research 2,423 citations
• The Adolescent Brain Cognitive Development (ABCD) study: Imaging acquisition across 21 sites 2,422 citations
• Revised American Thyroid Association Guidelines for the Management of Medullary Thyroid Carcinoma 2,421 citations
• A probabilistic atlas and reference system for the human brain: International Consortium for Brain Mapping (ICBM) 2,419 citations
• Collaborative Care Management of Late-Life Depression in the Primary Care Setting 2,419 citations
• 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the Diagnosis and Management of Patients With Stable Ischemic Heart Disease: Executive Summary 2,418 citations
• Comprehensive genomic profiles of small cell lung cancer 2,417 citations
• Functional Gastroduodenal Disorders 2,417 citations
• Effect of Vasodilator Therapy on Mortality in Chronic Congestive Heart Failure 2,416 citations
• Differential oestrogen receptor binding is associated with clinical outcome in breast cancer 2,413 citations
• Diagnosis and Management of Childhood Obstructive Sleep Apnea Syndrome 2,411 citations
• Prognostic Factors Analysis of 17,600 Melanoma Patients: Validation of the American Joint Committee on Cancer Melanoma Staging System 2,409 citations
• Tumor Mutational Burden as an Independent Predictor of Response to Immunotherapy in Diverse Cancers 2,408 citations
• CONSORT 2010 explanation and elaboration: Updated guidelines for reporting parallel group randomised trials 2,407 citations
• Recommended methods for determining responsiveness and minimally important differences for patient-reported outcomes 2,406 citations
• Historical (1850–2000) gridded anthropogenic and biomass burning emissions of reactive gases and aerosols: methodology and application 2,406 citations
• Inborn errors of type I IFN immunity in patients with life-threatening COVID-19 2,404 citations
• The Failing Heart — An Engine Out of Fuel 2,401 citations
• Incorporation of Bevacizumab in the Primary Treatment of Ovarian Cancer 2,398 citations
• Reactive oxygen species, toxicity, oxidative stress, and antioxidants: chronic diseases and aging 2,398 citations
• The Environment of Childhood Poverty. 2,397 citations
• GRADE guidelines: 7. Rating the quality of evidence—inconsistency 2,397 citations
• Vitamin D Deficiency and Risk of Cardiovascular Disease 2,397 citations
• Lung Cancer 2,397 citations
• Neurodegenerative Diseases Target Large-Scale Human Brain Networks 2,395 citations
• Clinical Characteristics of Covid-19 in New York City 2,394 citations
• Prevalence of mental disorders in China: a cross-sectional epidemiological study 2,393 citations
• A definition and classification of status epilepticus – Report of the <scp>ILAE</scp> Task Force on Classification of Status Epilepticus 2,391 citations
• The Metabolic Syndrome: Time for a Critical Appraisal 2,391 citations
• 2007 Guidelines for the management of arterial hypertension: The Task Force for the Management of Arterial Hypertension of the European Society of Hypertension (ESH) and of the European Society of Cardiology (ESC) 2,390 citations
• Antipsychotic-Induced Weight Gain: A Comprehensive Research Synthesis 2,389 citations
• Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 2,388 citations
• The ATLAS Experiment at the CERN Large Hadron Collider 2,387 citations
• Interleukin-1 polymorphisms associated with increased risk of gastric cancer 2,385 citations
• International variation in the prevalence of COPD (The BOLD Study): a population-based prevalence study 2,384 citations
• Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction 2,383 citations
• Three decades of global methane sources and sinks 2,382 citations
• Arabidopsis AtMYC2 (bHLH) and AtMYB2 (MYB) Function as Transcriptional Activators in Abscisic Acid Signaling 2,382 citations
• ShapeNet: An Information-Rich 3D Model Repository 2,381 citations
• Landscape of somatic mutations in 560 breast cancer whole-genome sequences 2,380 citations
• Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation 2,380 citations
• A systematic review and meta-analysis of the psychosis continuum: evidence for a psychosis proneness–persistence–impairment model of psychotic disorder 2,379 citations
• Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria 2,378 citations
• Laminin–a glycoprotein from basement membranes. 2,371 citations
• Molecular Genetics of Attention-Deficit/Hyperactivity Disorder 2,371 citations
• Identification of a CpG Island Methylator Phenotype that Defines a Distinct Subgroup of Glioma 2,370 citations
• Methods for Trend Estimation from Summarized Dose-Response Data, with Applications to Meta-Analysis 2,369 citations
• Industry 4.0 and Industry 5.0—Inception, conception and perception 2,369 citations
• Molecular Profiling Reveals Biologically Discrete Subsets and Pathways of Progression in Diffuse Glioma 2,367 citations
• Migraine prevalence, disease burden, and the need for preventive therapy 2,364 citations
• A rapid advice guideline for the diagnosis and treatment of 2019 novel coronavirus (2019-nCoV) infected pneumonia (standard version) 2,364 citations
• EDC-2: The Endocrine Society's Second Scientific Statement on Endocrine-Disrupting Chemicals 2,363 citations
• Fracture and Dislocation Classification Compendium - 2007 2,362 citations
• Association Between Administration of Systemic Corticosteroids and Mortality Among Critically Ill Patients With COVID-19 2,362 citations
• Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs 2,361 citations
• Infliximab (chimeric anti-tumour necrosis factor α monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial 2,360 citations
• Lixisenatide in Patients with Type 2 Diabetes and Acute Coronary Syndrome 2,360 citations
• The Effects of Dietary Protein Restriction and Blood-Pressure Control on the Progression of Chronic Renal Disease 2,357 citations
• Impaired recognition of emotion in facial expressions following bilateral damage to the human amygdala 2,356 citations
• PD-L1 Expression as a Predictive Biomarker in Cancer Immunotherapy 2,356 citations
• Use of Tumor-Infiltrating Lymphocytes and Interleukin-2 in the Immunotherapy of Patients with Metastatic Melanoma 2,356 citations
• GUIDE-seq enables genome-wide profiling of off-target cleavage by CRISPR-Cas nucleases 2,354 citations
• Mapping cortical change across the human life span 2,353 citations
• MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts 2,353 citations
• Global Spread of Carbapenemase-producing<i>Enterobacteriaceae</i> 2,352 citations
• Effective techniques in healthy eating and physical activity interventions: A meta-regression. 2,352 citations
• The definition, classification, and prognosis of chronic kidney disease: a KDIGO Controversies Conference report 2,350 citations
• Serotonin Transporter Genetic Variation and the Response of the Human Amygdala 2,350 citations
• Human Infection with a Novel Avian-Origin Influenza A (H7N9) Virus 2,349 citations
• A Multidisciplinary Intervention to Prevent the Readmission of Elderly Patients with Congestive Heart Failure 2,349 citations
• Guidelines for the Diagnosis and Management of Food Allergy in the United States: Summary of the NIAID-Sponsored Expert Panel Report 2,348 citations
• Worldwide access to treatment for end-stage kidney disease: a systematic review 2,348 citations
• A Developmental Perspective on the Role of Motor Skill Competence in Physical Activity: An Emergent Relationship 2,347 citations
• ESC Guidelines for the management of grown-up congenital heart disease (new version 2010): The Task Force on the Management of Grown-up Congenital Heart Disease of the European Society of Cardiology (ESC) 2,346 citations
• A polymorphic DNA marker genetically linked to Huntington's disease 2,346 citations
• National Sleep Foundation’s updated sleep duration recommendations: final report 2,345 citations
• Variable Selection for Propensity Score Models 2,345 citations
• Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder 2,345 citations
• Online Learning for Matrix Factorization and Sparse Coding 2,344 citations
• Per- and Polyfluoroalkyl Substance Toxicity and Human Health Review: Current State of Knowledge and Strategies for Informing Future Research 2,344 citations
• Crosstalk between cancer-associated fibroblasts and immune cells in the tumor microenvironment: new findings and future perspectives 2,344 citations
• A Bayesian method for the induction of probabilistic networks from data 2,344 citations
• Familial Hemiplegic Migraine and Episodic Ataxia Type-2 Are Caused by Mutations in the Ca2+ Channel Gene CACNL1A4 2,343 citations
• Genome-wide association study identifies novel breast cancer susceptibility loci 2,342 citations
• International consensus guidelines 2012 for the management of IPMN and MCN of the pancreas 2,342 citations
• M-Type Phospholipase A ₂ Receptor as Target Antigen in Idiopathic Membranous Nephropathy 2,338 citations
• Sequencing of 53,831 diverse genomes from the NHLBI TOPMed Program 2,337 citations
• The Role of Google Scholar in Evidence Reviews and Its Applicability to Grey Literature Searching 2,336 citations

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