CAR-T cell therapy research

TopicLeading institutions, researchers & key papers

This cluster of papers focuses on Chimeric Antigen Receptor (CAR) T cell therapy, a form of immunotherapy that uses genetically engineered T cells to target and destroy cancer cells. The papers cover various aspects of CAR T cell therapy, including its application in treating leukemia, lymphoma, and solid tumors, the management of cytokine release syndrome associated with this therapy, and the long-term efficacy and safety of CAR T cell treatment.

429

Works

IDs:OpenAlex

How has CAR-T cell therapy research's publication output changed over time?

ScholarIQpublication output · 2003–2021

Output grew100% over the shown period — from 1 works in 2003 to 2 in 2021.

2003200520062011201420162017201820192021

What are the most-cited papers on CAR-T cell therapy research?

ScholarIQmost cited works

Tisagenlecleucel in Children and Young Adults with B-Cell Lymphoblastic Leukemia

Shannon L. Maude, Theodore W. Laetsch, Jochen Buechner, Susana Rives, Michael Boyer, Henrique Bittencourt, Peter Bader, Michael R. Verneris, Heather E. Stefanski, Gary D. Myers, Muna Qayed, Barbara De Moerloose, Hidefumi Hiramatsu, Krysta Schlis, Kara L. Davis, Paul L. Martin, Eneida R. Nemecek, Gregory A. Yanik, Christina Peters, André Baruchel, Nicolas Boissel, Françoise Méchinaud, Adriana Balduzzi, Joerg Krueger, Carl H. June, Bruce L. Levine, Patricia A. Wood, Tetiana Taran, Mimi Leung, Karen T. Mueller, Yiyun Zhang, Kapildeb Sen, David Lebwohl, Michael A. Pulsipher, Stephan A. Grupp

New England Journal of Medicine. 20185,720 CitationsOPEN ACCESS

Dissecting the multicellular ecosystem of metastatic melanoma by single-cell RNA-seq

Itay Tirosh, Benjamin Izar, Sanjay M. Prakadan, Marc H. Wadsworth, Daniel J. Treacy, John J. Trombetta, Asaf Rotem, Christopher Rodman, Christine G. Lian, Gëorge F. Murphy, Mohammad Fallahi‐Sichani, Ken Dutton‐Regester, Jia‐Ren Lin, Ofir Cohen, Parin Shah, Diana Lu, Alex S. Genshaft, Travis K. Hughes, Carly G.K. Ziegler, Samuel W. Kazer, Aleth Gaillard, Kellie E. Kolb, Alexandra–Chloé Villani, Cory M. Johannessen, Aleksandr Andreev, Eliezer M. Van Allen, Monica M. Bertagnolli, Peter K. Sorger, Ryan J. Sullivan, Keith T. Flaherty, Dennie T. Frederick, Judit Jané‐Valbuena, Charles H. Yoon, Orit Rozenblatt–Rosen, Alex K. Shalek, Aviv Regev, Levi A. Garraway

Science. 20165,358 CitationsOPEN ACCESS

<i>LMO2</i> -Associated Clonal T Cell Proliferation in Two Patients after Gene Therapy for SCID-X1

S. Hacein-Bey-Abina, Christof von Kalle, Manfred Schmidt, Matthew P. McCormack, N. M. Wulffraat, Philippe Leboulch, Apiradee Lim, Cameron S. Osborne, Robert Pawliuk, Estelle Morillon, Ricardo U. Sorensen, A. Förster, Peter Fraser, J. I. Cohen, Geneviève de Saint Basile, Ian E. Alexander, Uwe Wintergerst, Thierry Frébourg, Alain Aurias, Dominique Stoppa‐Lyonnet, Serge Romana, I Radford-Weiss, Fabian Gross, F Valensi, Éric Delabesse, Elizabeth Macintyre, F Sigaux, Jean Soulier, Lily E. Leiva, Manuela Wissler, Claudia Prinz, Terence H. Rabbitts, Françoise Le Deist, Alain Fischer, Marina Cavazzana

Science. 20033,556 Citations

T cells expressing CD19 chimeric antigen receptors for acute lymphoblastic leukaemia in children and young adults: a phase 1 dose-escalation trial

Daniel W Lee, James N. Kochenderfer, Maryalice Stetler‐Stevenson, Yongzhi Cui, Cindy Delbrook, Steven A. Feldman, Terry J. Fry, Rimas J. Orentas, Marianna Sabatino, Nirali N. Shah, Seth M. Steinberg, D. Stroncek, Nick Tschernia, Constance M. Yuan, Hua Zhang, Ling Zhang, Steven A. Rosenberg, Alan S. Wayne, Crystal L. Mackall

The Lancet. 20142,953 Citations

Cancer Regression in Patients After Transfer of Genetically Engineered Lymphocytes

Richard A. Morgan, Mark E. Dudley, John R. Wunderlich, Marybeth S. Hughes, James Chih‐Hsin Yang, Richard M. Sherry, Richard E. Royal, Suzanne L. Topalian, Udai S. Kammula, Nicholas P. Restifo, Zhili Zheng, Azam Nahvi, Christiaan R. de Vries, Linda Rogers-Freezer, Sharon Mavroukakis, Steven A. Rosenberg

Science. 20062,581 CitationsOPEN ACCESS