Phosphodiesterase function and regulation

TopicLeading institutions, researchers & key papers

This cluster of papers focuses on the molecular regulation and clinical applications of cyclic nucleotide phosphodiesterases (PDEs), particularly in the context of cAMP signaling, schizophrenia genetics, neuronal development, therapeutic targeting, compartmentalized signaling, Alzheimer's disease treatment, cardiac function regulation, and the development of phosphodiesterase inhibitors.

Works

IDs:OpenAlex

How has Phosphodiesterase function and regulation's publication output changed over time?

ScholarIQpublication output · 1998–2019

Output grew0% over the shown period — from 1 works in 1998 to 1 in 2019.

1998199920052006201020142015201620182019

What are the most-cited papers on Phosphodiesterase function and regulation?

ScholarIQmost cited works

Phosphodiesterase-5 inhibition augments endogenous antitumor immunity by reducing myeloid-derived suppressor cell function

Paolo Serafini, Kristen F. Meckel, Michael J. Kelso, Kimberly Noonan, Joseph A. Califano, Wayne M. Koch, Luigi Dolcetti, Vincenzo Bronte, Ivan Borrello

S22947807. 2006757 CitationsOPEN ACCESS

Phosphodiesterase-4 Inhibitors for the Treatment of Inflammatory Diseases

Heng Li, Jianping Zuo, Wei Tang

Frontiers in Pharmacology. 2018572 CitationsOPEN ACCESS

Efficacy and safety of apremilast, an oral phosphodiesterase 4 inhibitor, in patients with moderate‐to‐severe plaque psoriasis over 52 weeks: a phase III, randomized controlled trial (ESTEEM 2)

C. Paul, Jennifer Clay Cather, Melinda Gooderham, Yves Poulin, Ulrich Mrowietz, C. Ferrandiz, J. Crowley, ChiaChi Hu, R.M. Stevens, Kara N. Shah, R. M. Day, Giampiero Girolomoni, A.B. Gottlieb

British Journal of Dermatology. 2015480 CitationsOPEN ACCESS

Association of DISC1/TRAX Haplotypes With Schizophrenia, Reduced Prefrontal Gray Matter, and Impaired Short- and Long-term Memory

Tyrone D. Cannon, William Hennah, Theo G.M. van Erp, Paul M. Thompson, Jouko Lönnqvist, Matti Huttunen, Timothy L. Gasperoni, Annamari Tuulio‐Henriksson, Tia Pirkola, Arthur W. Toga, Jaakko Kaprio, John C. Mazziotta, Leena Peltonen

S126359496. 2005341 CitationsOPEN ACCESS

Apremilast, an oral phosphodiesterase 4 inhibitor, in patients with psoriatic arthritis and current skin involvement: a phase III, randomised, controlled trial (PALACE 3)

Christopher J Edwards, Francisco J. Blanco, Jeffrey Crowley, C. Birbara, Janusz Jaworski, Jacob Aelion, Randall M. Stevens, Adele R. Vessey, Xiaojiang Zhan, Paul Bird

Annals of the Rheumatic Diseases. 2016286 CitationsOPEN ACCESS