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PI3K/AKT/mTOR signaling in cancer

TopicLeading institutions, researchers & key papers

PI3K/AKT/mTOR signaling in cancer is a topic indexed in ScholarIQ from OpenAlex.

What is known about PI3K/AKT/mTOR signaling in cancer?

ScholarIQrecord summary

This cluster of papers focuses on the mTOR signaling pathway, particularly its role in growth control, metabolism, and disease, with a specific emphasis on cancer. The PI3K/AKT pathway, Raptor, TSC2, and rapamycin are central to the research discussed in these papers.

How many works does PI3K/AKT/mTOR signaling in cancer have?

ScholarIQindexed works

PI3K/AKT/mTOR signaling in cancer has 223 works in the ScholarIQ index. The count is the OpenAlex total, not the number of papers listed on this page.

What is the OpenAlex record for PI3K/AKT/mTOR signaling in cancer?

ScholarIQopenalex

The OpenAlex for PI3K/AKT/mTOR signaling in cancer is on the source record.

What are the most-cited papers on PI3K/AKT/mTOR signaling in cancer?

ScholarIQmost cited works
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman, Ji Luo, Lewis C. Cantley
Nature Reviews Genetics. 20063,323 Citations
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Jeffrey A. Engelman
Nature reviews. Cancer. 20092,466 Citations
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
A Ullrich, Jeffrey R. Bell, E. Y. Chen, Román Herrera, Lilli Petruzzelli, Thomas J. Dull, Andrew Gray, Lisa M. Coussens, Yiwen Liao, Makoto Tsubokawa, Anthony J. Mason, P. H. Seeburg, Carl Grünfeld, O M Rosen, J. Ramachandran
Nature. 19852,270 Citations
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
Markus Guba, Philipp von Breitenbuch, Markus Steinbauer, Gudrun E. Koehl, Stefanie Flegel, Matthias Hornung, Christiane J. Bruns, Carl Zuelke, Stefan Farkas, Matthias Anthuber, Karl‐Walter Jauch, Edward K. Geissler
Nature Medicine. 20021,738 Citations
Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the <i>Pten</i> Tumor Suppressor Gene in Vivo
Matthias Groszer, Rebecca J. Erickson, Deirdre D. Scripture-Adams, Ralf Lesche, Andreas Trumpp, Jerome A. Zack, Harley I. Kornblum, Xin Liu, Hong Wu
Science. 2001794 CitationsOPEN ACCESS

Where is PI3K/AKT/mTOR signaling in cancer research published, and who funds it?

ScholarIQvenues & funding sources

TOP FUNDERS

National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
Funder breakdown is a member featureSign up free to unlock

How much of the research on PI3K/AKT/mTOR signaling in cancer is open access?

ScholarIQopen access share
53%OPEN ACCESS
Gold
13%
Green
7%
Hybrid
7%
Bronze
27%
Closed
47%

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