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PI3K/AKT/mTOR signaling in cancer
TopicLeading institutions, researchers & key papers
This cluster of papers focuses on the mTOR signaling pathway, particularly its role in growth control, metabolism, and disease, with a specific emphasis on cancer. The PI3K/AKT pathway, Raptor, TSC2, and rapamycin are central to the research discussed in these papers.
223
Works
IDs:OpenAlex
How has PI3K/AKT/mTOR signaling in cancer's publication output changed over time?
ScholarIQpublication output · 2002–2019
Output declined50% over the shown period — from 2 works in 2002 to 1 in 2019.
2
1
1
1
2
1
2
1
1
1
2002200520062007200820092014201520172019
What are the most-cited papers on PI3K/AKT/mTOR signaling in cancer?
ScholarIQmost cited works
The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
Jeffrey A. Engelman, Ji Luo, Lewis C. Cantley
S8553189. 20063,323 Citations
Targeting PI3K signalling in cancer: opportunities, challenges and limitations
Jeffrey A. Engelman
S160464432. 20092,466 Citations
Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
A Ullrich, Jeffrey R. Bell, E. Y. Chen, Román Herrera, Lilli Petruzzelli, Thomas J. Dull, Andrew Gray, Lisa M. Coussens, Yiwen Liao, Makoto Tsubokawa, Anthony J. Mason, P. H. Seeburg, Carl Grünfeld, O M Rosen, J. Ramachandran
Nature. 19852,270 Citations
Rapamycin inhibits primary and metastatic tumor growth by antiangiogenesis: involvement of vascular endothelial growth factor
Markus Guba, Philipp von Breitenbuch, Markus Steinbauer, Gudrun E. Koehl, Stefanie Flegel, Matthias Hornung, Christiane J. Bruns, Carl Zuelke, Stefan Farkas, Matthias Anthuber, Karl‐Walter Jauch, Edward K. Geissler
Nature Medicine. 20021,738 Citations
Negative Regulation of Neural Stem/Progenitor Cell Proliferation by the <i>Pten</i> Tumor Suppressor Gene in Vivo
Matthias Groszer, Rebecca J. Erickson, Deirdre D. Scripture-Adams, Ralf Lesche, Andreas Trumpp, Jerome A. Zack, Harley I. Kornblum, Xin Liu, Hong Wu
Science. 2001794 CitationsOPEN ACCESS
Where is PI3K/AKT/mTOR signaling in cancer research published, and who funds it?
ScholarIQvenues & funding sources
TOP JOURNALS
TOP FUNDERS
National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
Funder breakdown is a member featureSign up free to unlock
How much of the research on PI3K/AKT/mTOR signaling in cancer is open access?
ScholarIQopen access share
53%OPEN ACCESS
Gold
13%
Green
7%
Hybrid
7%
Bronze
27%
Closed
47%
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The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism
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Targeting PI3K signalling in cancer: opportunities, challenges and limitations
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Human insulin receptor and its relationship to the tyrosine kinase family of oncogenes
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