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Protein Degradation and Inhibitors
TopicLeading institutions, researchers & key papers
This cluster of papers focuses on the targeted degradation of specific proteins, particularly through the use of BET bromodomain inhibitors and PROTACs. The research explores the therapeutic potential of this approach, with a focus on histone recognition, small molecule inhibitors, and the role of epigenetic readers in transcriptional regulation. Additionally, it investigates the use of cereblon-dependent degradation and its implications for drug discovery.
133
Works
IDs:OpenAlex
How has Protein Degradation and Inhibitors's publication output changed over time?
ScholarIQpublication output · 2000–2023
Output grew0% over the shown period — from 1 works in 2000 to 1 in 2023.
1
1
4
2
3
2
1
1
20002013201520162017201820202023
What are the most-cited papers on Protein Degradation and Inhibitors?
ScholarIQmost cited works
Catalytic in vivo protein knockdown by small-molecule PROTACs
Daniel P. Bondeson, Alina Mares, Ian E. Smith, Eunhwa Ko, Sébastien Campos, Afjal H. Miah, Katie E Mulholland, Natasha Routly, Dennis L. Buckley, Jeffrey L. Gustafson, Nico Zinn, Paola Grandi, Satoko Shimamura, Giovanna Bergamini, Maria Faelth-Savitski, Marcus Bantscheff, Carly S. Cox, Deborah A. Gordon, Ryan R. Willard, John J. Flanagan, Linda Casillas, Bartholomew J. Votta, Willem den Besten, Kristoffer Famm, Laurens Kruidenier, Paul S. Carter, John D. Harling, Ian Churcher, Craig M. Crews
S51309854. 20151,338 CitationsOPEN ACCESS
Hijacking the E3 Ubiquitin Ligase Cereblon to Efficiently Target BRD4
Jing Lü, Yimin Qian, Martha Altieri, Hanqing Dong, Jing Wang, Kanak Raina, John Hines, James D. Winkler, Andrew P. Crew, Kevin Coleman, Craig M. Crews
S85134406. 20151,155 CitationsOPEN ACCESS
Lessons in PROTAC Design from Selective Degradation with a Promiscuous Warhead
Daniel P. Bondeson, Blake E. Smith, George M. Burslem, Alexandru D. Buhimschi, John Hines, Saul Jaime‐Figueroa, Jing Wang, Brian D. Hamman, Alexey Ishchenko, Craig M. Crews
S4210231961. 2017918 CitationsOPEN ACCESS
PROTAC-induced BET protein degradation as a therapy for castration-resistant prostate cancer
Kanak Raina, Jing Lü, Yimin Qian, Martha Altieri, Deborah Gordon, Ann Marie Rossi, Jing Wang, Xin Chen, Hanqing Dong, Kam Siu, James D. Winkler, Andrew P. Crew, Craig M. Crews, Kevin Coleman
Proceedings of the National Academy of Sciences. 2016847 CitationsOPEN ACCESS
The Advantages of Targeted Protein Degradation Over Inhibition: An RTK Case Study
George M. Burslem, Blake E. Smith, Ashton C. Lai, Saul Jaime‐Figueroa, Daniel McQuaid, Daniel P. Bondeson, Momar Toure, Hanqing Dong, Yimin Qian, Jing Wang, Andrew P. Crew, John Hines, Craig M. Crews
S4210231961. 2017685 CitationsOPEN ACCESS
Where is Protein Degradation and Inhibitors research published, and who funds it?
ScholarIQvenues & funding sources
TOP JOURNALS
TOP FUNDERS
National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
Funder breakdown is a member featureSign up free to unlock
How much of the research on Protein Degradation and Inhibitors is open access?
ScholarIQopen access share
87%OPEN ACCESS
Gold
13%
Green
33%
Hybrid
0%
Bronze
40%
Closed
13%
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