Statistical Methods in Clinical Trials

TopicLeading institutions, researchers & key papers

This cluster of papers covers a wide range of statistical methods and design considerations in the context of clinical trials and drug development. It includes topics such as controlling the false discovery rate, adaptive trial designs, noninferiority trials, biomarkers, phase I trials, multiple testing, Bayesian methods, sample size determination, composite endpoints, and pharmacokinetic/pharmacodynamic modeling.

194

Works

IDs:OpenAlex

How has Statistical Methods in Clinical Trials's publication output changed over time?

ScholarIQpublication output · 1988–2016

Output grew0% over the shown period — from 1 works in 1988 to 1 in 2016.

1988199620042005200620082012201320142016

What are the most-cited papers on Statistical Methods in Clinical Trials?

ScholarIQmost cited works

Investigation of the freely available easy-to-use software ‘EZR’ for medical statistics

Yoshinobu Kanda

S183182149. 201219,017 CitationsOPEN ACCESS

MULTIVARIABLE PROGNOSTIC MODELS: ISSUES IN DEVELOPING MODELS, EVALUATING ASSUMPTIONS AND ADEQUACY, AND MEASURING AND REDUCING ERRORS

Frank E. Harrell, Kerry L. Lee, Daniel B. Mark

S55189604. 19969,866 Citations

Tutorial in biostatistics: competing risks and multi‐state models

Hein Putter, Marta Fiocco, Ronald B. Geskus

S55189604. 20062,435 Citations

The Prevention and Treatment of Missing Data in Clinical Trials

Roderick J. A. Little, Ralph B. D’Agostino, Michael L. Cohen, Kay Dickersin, Scott S. Emerson, John T. Farrar, Constantine Frangakis, Joseph W. Hogan, Geert Molenberghs, Susan A. Murphy, James D. Neaton, Andrea Rotnitzky, Daniel O. Scharfstein, Weichung Joe Shih, Jay P. Siegel, Hal S. Stern

New England Journal of Medicine. 20121,913 CitationsOPEN ACCESS

Calculating measures of biological interaction

Tomas Andersson, Lars Alfredsson, Henrik Källberg, Slobodan Zdravković, Anders Ahlbom

European Journal of Epidemiology. 20051,541 Citations