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Synthesis and Biological Activity
TopicLeading institutions, researchers & key papers
This cluster of papers focuses on the chemistry, biology, and synthesis of antitumor antibiotics, particularly tetrahydroisoquinoline compounds such as Ecteinascidin. It covers topics such as total synthesis, marine-derived compounds, asymmetric synthesis, and DNA binding mechanisms. The research also explores the pharmacological activities and potential clinical utility of these compounds.
20
Works
IDs:OpenAlex
How has Synthesis and Biological Activity's publication output changed over time?
ScholarIQpublication output · 2000–2013
Output grew0% over the shown period — from 1 works in 2000 to 1 in 2013.
1
1
2
1
1
1
200020012002200320092013
What are the most-cited papers on Synthesis and Biological Activity?
ScholarIQmost cited works
Phase I and Pharmacokinetic Study of Ecteinascidin-743, a New Marine Compound, Administered as a 24-hour Continuous Infusion in Patients With Solid Tumors
A. Taamma, J. L. Misset, M. Riofrio, C. Guzmán, Étienne Brain, Luis López Lázaro, Hilde Rosing, José Jimeno, Esteban Cvitkovic
Journal of Clinical Oncology. 2001160 Citations
Yondelis® (trabectedin, ET-743): the development of an anticancer agent of marine origin
Ch. van Kesteren, M. M. M. de Vooght, Luis López Lázaro, Ron A. A. Mathôt, Jan H.M. Schellens, José Jimeno, Jos H. Beijnen
S158028025. 200387 Citations
A phase I and pharmacokinetic study of ecteinascidin-743 on a daily x 5 schedule in patients with solid malignancies.
Miguel A. Villalona‐Calero, S. Gail Eckhardt, Geoffrey R. Weiss, Manuel Hidalgo, Jos H. Beijnen, Charlotte van Kesteren, Hilde Rosing, Elizabeth Campbell, Maura A. Kraynak, Luis López Lázaro, Cecilia Guzmán, Daniel D. Von Hoff, José Jimeno, Eric K. Rowinsky
PubMed. 200282 Citations
Pharmacokinetics and pharmacodynamics of the novel marine-derived anticancer agent ecteinascidin 743 in a phase I dose-finding study.
Charlotte van Kesteren, Esteban Cvitkovic, A. Taamma, Luis López Lázaro, José Jimeno, C. Guzmán, R A Math t, Jan H.M. Schellens, J.L. Misset, E. Brain, M.J.X Hillebrand, Hilde Rosing, Jos H. Beijnen
PubMed. 200080 Citations
Antiproliferative and Apoptotic Activities of Linear Furocoumarins from<i>Notopterygium incisum</i>on Cancer Cell Lines
Shi‐Biao Wu, Fei Pang, Ying Wen, Hongfeng Zhang, Zheng Zhao, Jin‐Feng Hu
S39653451. 200969 Citations
Where is Synthesis and Biological Activity research published, and who funds it?
ScholarIQvenues & funding sources
TOP JOURNALS
TOP FUNDERS
National Science Foundation—
NIH—
Wellcome Trust—
European Research Council—
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How much of the research on Synthesis and Biological Activity is open access?
ScholarIQopen access share
14%OPEN ACCESS
Gold
0%
Green
0%
Hybrid
0%
Bronze
14%
Closed
86%
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Phase I and Pharmacokinetic Study of Ecteinascidin-743, a New Marine Compound, Administered as a 24-hour Continuous Infusion in Patients With Solid Tumors
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