Telomeres, Telomerase, and Senescence

TopicLeading institutions, researchers & key papers

This cluster of papers explores the mechanisms and implications of cellular senescence, with a focus on telomere dynamics, tumor suppression, inflammation, DNA damage response, and the potential therapeutic role of senolytics in aging-related diseases.

109

Works

IDs:OpenAlex

How has Telomeres, Telomerase, and Senescence's publication output changed over time?

ScholarIQpublication output · 1973–2021

Output grew0% over the shown period — from 1 works in 1973 to 1 in 2021.

1973199620022007201120132017201820192021

What are the most-cited papers on Telomeres, Telomerase, and Senescence?

ScholarIQmost cited works

A Human Cell Line From a Pleural Effusion Derived From a Breast Carcinoma 2

Herbert D. Soule, J. Vázquez, Anna Long, Steven M. Albert, Michael Brennan

JNCI Journal of the National Cancer Institute. 19732,465 Citations

Senolytics improve physical function and increase lifespan in old age

Ming Xu, Tamar Pirtskhalava, Joshua N. Farr, Bettina M. Weigand, Allyson K. Palmer, Megan Weivoda, Christina L. Inman, Mikołaj Ogrodnik, Christine Hachfeld, Daniel G. Fraser, Jennifer L Onken, Kurt O. Johnson, Grace Verzosa, Larissa G. P. Langhi, Moritz Weigl, Nino Giorgadze, Nathan K. LeBrasseur, Jordan D. Miller, Diana Jurk, Ravinder J. Singh, David B. Allison, Keisuke Ejima, Gene B. Hubbard, Yuji Ikeno, Hajrunisa Čubro, Vesna D. Garovic, Xiaonan Hou, S. John Weroha, Paul D. Robbins, Laura J. Niedernhofer, Sundeep Khosla, Tamar Tchkonia, James L. Kirkland

Nature Medicine. 20182,283 Citations

Senescence surveillance of pre-malignant hepatocytes limits liver cancer development

Tae-Won Kang, Tetyana Yevsa, Norman Woller, Lisa Hoenicke, Torsten Wüestefeld, Daniel Dauch, Anja Hohmeyer, Marcus Gereke, Ramona Rudalska, Anna Potapova, Marcus Iken, Mihael Vucur, Siegfried Weiß, Mathias Heikenwälder, Sadaf Khan, Jesús Gil, Dunja Bruder, Michael P. Manns, Peter Schirmacher, Frank Tacke, Michael Ott, Tom Luedde, Thomas Longerich, Stefan Kubicka, Lars Zender

Nature. 20111,591 Citations

<i>TERT</i> promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Patrick Killela, Zachary J. Reitman, Yuchen Jiao, Chetan Bettegowda, Nishant Agrawal, Luis A. Díaz, Allan H. Friedman, Henry S. Friedman, Gary L. Gallia, Beppino C. Giovanella, Arthur P. Grollman, Tong‐Chuan He, Yiping He, Ralph H. Hruban, George I. Jallo, Nils Mandahl, Alan K. Meeker, Fredrik Mertens, George J. Netto, B. Ahmed Rasheed, Gregory J. Riggins, Thomas A. Rosenquist, Mark Schiffman, Ie‐Ming Shih, Dan Theodorescu, Michael Torbenson, Victor E. Velculescu, Tian‐Li Wang, Nicolas Wentzensen, Laura D. Wood, Ming Zhang, Roger E. McLendon, Darell D. Bigner, Kenneth W. Kinzler, Bert Vogelstein, Nickolas Papadopoulos, Hai Yan

Proceedings of the National Academy of Sciences. 20131,382 CitationsOPEN ACCESS

Targeting cellular senescence prevents age-related bone loss in mice

Joshua N. Farr, Ming Xu, Megan Weivoda, David G. Monroe, Daniel G. Fraser, Jennifer L Onken, Brittany A Negley, Jad Sfeir, Mikołaj Ogrodnik, Christine Hachfeld, Nathan K. LeBrasseur, Matthew T. Drake, Robert J. Pignolo, Tamar Pirtskhalava, Tamar Tchkonia, Merry Jo Oursler, James L. Kirkland, Sundeep Khosla

Nature Medicine. 20171,165 CitationsOPEN ACCESS