Virus-based gene therapy research

TopicLeading institutions, researchers & key papers

This cluster of papers covers a wide range of topics related to gene therapy, including the use of viral vectors such as AAV and adenovirus, advancements in oncolytic virus therapy, hematopoietic stem cell gene therapy, immunodeficiency treatments, lentiviral vector applications, transgene expression, and genomic integration. The research reflects the ongoing progress and challenges in the field of gene therapy.

255

Works

IDs:OpenAlex

How has Virus-based gene therapy research's publication output changed over time?

ScholarIQpublication output · 1992–2020

Output grew100% over the shown period — from 1 works in 1992 to 2 in 2020.

1992199819992004200620132014201620182020

What are the most-cited papers on Virus-based gene therapy research?

ScholarIQmost cited works

Successful transduction of liver in hemophilia by AAV-Factor IX and limitations imposed by the host immune response

Catherine S. Manno, Glenn F. Pierce, Valder R. Arruda, Bertil Glader, Margaret V. Ragni, John E.J. Rasko, Margareth C. Ozelo, Keith Hoots, Philip M. Blatt, Barbara A. Konkle, Michael D. Dake, Robin Kaye, Mahmood Razavi, Albert Zajko, James L. Zehnder, Pradip K. Rustagi, Hiroyuki Nakai, Amy Chew, Debra G. B. Leonard, J Fraser Wright, Ruth Lessard, Jürg M. Sommer, Michael Tigges, Denise E. Sabatino, Alvin Luk, Haiyan Jiang, Federico Mingozzi, Linda Couto, Hildegund C.J. Ertl, Katherine A. High, Mark A. Kay

Nature Medicine. 20062,148 Citations

In Vivo Gene Transfer with Retroviral Vector-Producer Cells for Treatment of Experimental Brain Tumors

Kenneth W. Culver, Zvi Ram, Stuart Wallbridge, Hiroyuki Ishii, Edward H. Oldfield, R. Michael Blaese

Science. 19921,527 Citations

Safety, tolerability, and immunogenicity of a recombinant adenovirus type-5 vectored COVID-19 vaccine: a dose-escalation, open-label, non-randomised, first-in-human trial

Fengcai Zhu, Yu-Hua Li, Xu-Hua Guan, Li-Hua Hou, Wen-Juan Wang, Wen-Juan Wang, J X Li, Shi-Po Wu, Zhao Wang, Lei Wang, Lei Wang, Hu-Dachuan Jiang, Hu-Dachuan Jiang, Ling Wang, T Jiang, Yu Hu, Jin-Bo Gou, Junjie Xu, Junjie Xu, Wei Wang, Wei Chen, Wei Wang, Wei Chen

The Lancet. 20201,453 CitationsOPEN ACCESS

Immunogenicity and safety of a recombinant adenovirus type-5-vectored COVID-19 vaccine in healthy adults aged 18 years or older: a randomised, double-blind, placebo-controlled, phase 2 trial

Fengcai Zhu, Xu-Hua Guan, Yu-Hua Li, Jian-Ying Huang, Tao Jiang, Li-Hua Hou, Jingxin Li, Bei-Fang Yang, Ling Wang, Wen-Juan Wang, Shi-Po Wu, Zhao Wang, Xiao-Hong Wu, Junjie Xu, Zhe Zhang, Si-Yue Jia, Busen Wang, Yi Hu, Jing‐Jing Liu, Jun Zhang, Xiao-Ai Qian, Qiong Li, Hong-Xing Pan, Hu-Dachuan Jiang, Peng Deng, Jin-Bo Gou, Xue-Wen Wang, Xue-Wen Wang, Xinghuan Wang, Xinghuan Wang, Wei Chen

The Lancet. 20201,293 CitationsOPEN ACCESS

Clades of Adeno-Associated Viruses Are Widely Disseminated in Human Tissues

Guangping Gao, Luk H. Vandenberghe, Mauricio R. Alvira, You Lü, Roberto Calcedo, Xiangyang Zhou, James M. Wilson

S96615428. 20041,067 CitationsOPEN ACCESS