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potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour

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potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour is a researcher indexed in ScholarIQ from OpenAlex & ORCID.

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potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour has 1 works in the ScholarIQ index. The count is the OpenAlex total, not the number of papers listed on this page.

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potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour has 3 citations in the OpenAlex counts ScholarIQ stores.

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potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour has an h-index of 1 in OpenAlex.

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potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour has an i10-index of 0 in OpenAlex.

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Oral Abstract
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are chemogenetic tools for remote control of targeted cell populations using chemical actuators that bind to modified receptors. Despite the popularity of DREADDs in neuroscience and sleep research, potential effects of clozapine-N-oxide (CNO) and other DREADD actuators on sleep have never been systematically tested. Recent reports suggest that CNO can affect brain activity and animal behaviour, putatively through conversion to clozapine. The aim of our study was to assess whether CNO or compound 21 (C21), a novel actuator that cannot convert to clozapine, affect sleep in wild type laboratory mice.
Journal of Sleep Research. 20223 CitationsOPEN ACCESS

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